| Objective:By using Shuangshen Decoction to treat patients with stable angina pectoris of coronary heart disease(phlegm-stasis interjunction type),the changes of TCM syndrome score,angina pectoris symptom score,vascular endothelial function factor(ET-1),inflammatory factor(TNF-α),carotid intima-media thickness and carotid artery plaque area were observed.To investigate the clinical effect of Shuangshen Decoction on stable angina pectoris(phlegm-stasis interjunction type).Methods:A total of 64 patients diagnosed with stable angina pectoris(phlegm stasis interjunction type)of coronary heart disease were collected from the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from December 2021 to December 2022.According to the random number table method,the patients were divided into experimental group and control group,with 32 patients in experimental group and 32 in control group.The control group was given conventional Western medicine to treat basic diseases,and the experimental group was given Shuangshen decoction every day on the basis of the control group.The treatment cycle of both groups was 4 weeks.The efficacy indexes and safety observation indexes before and after treatment were observed and recorded,and the data were analyzed and processed using SPSS27.0 software.Results:1.TCM syndrome score:there was no statistical difference in the total TCM syndrome score between the two groups before treatment(P>0.05),and the total TCM syndrome score of the two groups after treatment was decreased compared with that before treatment(P<0.001),and the test group was significantly better than the control group(P<0.05).After treatment,the single syndromes of TCM in the experimental group were improved(P<0.05),while there was no statistical difference in the treatment of brown face and sticky stool in the control group(P>0.05),and the other single syndromes were improved(P<0.05).Compared between the two groups,there were no statistical differences in the treatment of mouth adhesion,body sleepiness,abdominal distension,drowsiness,dark complexion,skin nail malocclusion,dark complexion,extremities terminal cyanosis(P>0.05),and the experimental group was better than the control group in improving chest pain,chest tightness,phlegm and stool viscosity(P<0.05).The effective rate of TCM syndrome in the experimental group was 77.42%,and 55.17%in the control group,which was significantly better than that in the control group(P<0.05).2.Angina symptom score:there was no statistical difference in angina symptom score between the two groups before treatment(P>0.05).After treatment,angina symptom score of the two groups decreased significantly compared with that before treatment(P<0.001),and the effect of the experimental group was better than that of the control group(P<0.05).The total effective rate of angina pectoris was 93.55%in experimental group and 72.41%in control group,and the experimental group was significantly better than the control group(P<0.05).3.Serum ET-1 and TNF-α levels:Before treatment,there was no statistical difference in the contents of ET-1 and TNF-α in serum between the two groups(P>0.05),and after treatment,the contents of ET-1 and TNF-α in serum between the two groups were significantly decreased compared with that before treatment(P<0.001),and the experimental group was better than the control group(P<0.001).4.IMT and total carotid plaque area:There were no significant differences in IMT values between the two groups before treatment(P>0.05),no significant differences in IMT values between the two groups after treatment(P>0.05),and no significant differences between the experimental group and the control group(P>0.05).There was no statistical difference in the total area of carotid artery plaque between the two groups before treatment(P>0.05),the total area of carotid artery plaque after treatment in the control group was not statistically different from that before treatment(P>0.05),the total area of carotid artery plaque after treatment in the experimental group was reduced compared with that before treatment(P<0.05),and the total area of carotid artery plaque in the experimental group was better than that in the control group(P<0.05).Conclusion:1.Shuangshen Decoction can reduce the total TCM syndrome score and single TCM syndrome score of patients with stable angina pectoris(phlegmstasis interjunction type),and improve the efficiency of TCM syndrome;2.Shuangshen Decoction can reduce angina symptom score and improve angina symptom in patients with stable angina pectoris(phlegm-stasis interjunction type).3.Shuangshen Decoction can reduce the serum levels of ET-1 and TNF-αin patients with stable angina pectoris(phlegm-stasis interjunction type).4.Shuangshen Decoction can reduce the total area of carotid artery plaque in patients with stable angina pectoris(phlegm-stasis interjunction type),but has no significant improvement on IMT value. |
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