Correlation Analysis Of Neck Circumference And Metabolic Syndrome In Polycystic Ovary Syndrome With Phlegm-dampness Syndrome

Objective:To compare the general clinical characteristics of patients with phlegm-damp PCOS（Polycystic Ovary Syndrome,PCOS）with MS（Metabolic syndrome,MS）,to analyse the differences in the clinical characteristics of NC（Neck circumference,NC）quartiles in patients with phlegm-damp PCOS with MS,to explore the relationship between NC and the risk of disease in patients with phlegm-damp PCOS with MS,and to predict the risk factors associated with abnormal NC in patients with phlegm-damp PCOS with MS.Methods:Seven hundred and thirty-five patients with PCOS,aged between 18 and40 years old,who met the inclusion criteria from February 2021 to May 2023at Heilongjiang University of Chinese Medicine were selected.Firstly,they were divided into 464 cases in the phlegm-damp evidence group and 271cases in the non-phlegm-damp evidence group,and the general clinical characteristics of the 2 groups were compared.Secondly,the 464 patients with phlegm and dampness were divided into the phlegm and dampness PCOS with MS group and the PCOS without MS group according to the MS diagnostic criteria,and the differences between the two groups were compared.Finally,357 patients with phlegm-damp PCOS with MS group were divided into NC level normal group and NC level abnormal group,and a multi-factor logistic regression analysis model was constructed to investigate the independent risk factors of NC level and the risk of MS in patients with phlegm-damp PCOS,and then the differences in clinical characteristics between the groups in the quartiles of abnormal NC level were compared and correlation analysis was performed.Results:1.In this study,age,WHR,TC and LDL-C of PCOS patients in the phlegm-damp evidence group were significantly different from those in the non-phlegm-damp evidence group（P<0.05）,while SBP,DBP,weight,BMI,WC,HC,NC,SHBG,FINS,I₁₂₀,HOMA-IR,APO-A,APO-B and Lp（a）were significantly higher than those in the non-phlegm-damp evidence group（P<0.05）.2.In this study,LH and LH/FSH of PCOS patients with MS in the phlegm-damp evidence group were significantly different from those in the phlegm-damp evidence group without MS（P<0.05）,while age,SBP,DBP,weight,BMI,WC,HC,NC,WHR,DHEAS,SHBG,FPG,G₁₂₀,FINS,I₁₂₀,HOMA-IR,TG,LD（a）,and Lp（a）were significantly higher than those in the non-phlegm-damp evidence group（P<0.05）,TC,HDL-C,LDL-C,APO-A,APO-B and Lp（a）were significantly higher than those in the group with phlegm and dampness without MS（P<0.05）.3.Whether NC was normal in the PCOS with MS patients with phlegm-damp evidence group was included in the multi-factor logistic regression analysis.The results showed that PRL,FPG,HOMA-IR and TG were independent risk factors for abnormal NC in patients with PCOS with MS with phlegm and dampness（P<0.05）.4.The clinical characteristics of NC in patients with PCOS with MS with phlegm and dampness were compared in quartile groups,and the results showed that the levels of DBP,weight,BMI,FPG,FINS and HOMA-IR increased with increasing NC,and the differences were all statistically significant（P<0.05）.Conclusions:1.Patients with PCOS with phlegm and dampness had more significant abnormalities in glucose and lipid metabolism levels compared to those with non-phlegm and dampness.2.Patients with phlegm-damp PCOS with MS had higher levels of IR and NC compared to those without MS.3.Patients with PCOS with MS with phlegm-dampness evidence of NC irregularities progressively worsen with progressively higher PRL,FPG,HOMA-IR and TG levels.4.NC is strongly associated with the development of MS in patients with sputum wet PCOS,and the risk of MS increases with the increase of NC levels.