Clinical Observation Of Jianpi Huatan Pingchuan Prescription In Treating Chronic Persistent Bronchialasthma(Syndrome Of Deficiency Of Lung And Spleen Qi And Obstruction Of Phlegm) And Its Effect On Serum VEGF

Objective: To observe the effects of Jianpi Huatan Pingchuan prescription on symptom and sign scores,ACT scores and serum VEGF in the chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm).To evaluate its efficacy and safety.Methods: In this study,70 patients with chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm)who met the requirements were collected from the outpatient department of Respiratory Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from December 01,2021 to December 31,2022.They were randomly divided into the treatment group and the control group by single blind method.In the experiment,1 case was lost to follow-up in the treatment group,1 case progressed and was hospitalized in the control group,and 1 case was not removed according to the course of medication.Finally,34 patients in the treatment group and 33 in the control group.The control group was treated with the treatment method of Seretide(specification: 50μg salmeterol /250μg fluticasone propionate ×60),1 dose each time,2 times a day.On this basis,the treatment group was given Jianpi Huatan Pingchuanfang,1 dose a day,300 ml,twice in the morning and evening.The course of treatment was 4 weeks.The changes of symptom and sign scores,ACT scores,serum VEGF and safety indexes before and after treatment were observed in the two groups.Results:1.The total scores,primary and secondary scores of both groups were improved after treatment(P<0.05),and the treatment group was better than the control group(P<0.05);2.The total effective rate of the treatment group was 94.12%,and that of the control group was 81.82%,and the treatment group was better than the control group(P<0.05);3.Wheezing scores in both groups were improved after treatment(P<0.05),and the treatment group was better than the control group(P<0.05);4.The ACT scores of both groups were improved after treatment,and the treatment group was higher than the control group(P<0.05);5.After treatment,the serum VEGF level in both groups decreased(P<0.05),and that in the treatment group was lower than that in the control group(P<0.05).6.There were no obvious abnormalities in the safety indexes of the two groups before and after treatment.Conclusion:1.Jianpi Huatan Pingchuan prescription can improve the TCM syndrome score of patients with chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm);2.Jianpi Huatan Pingchuan prescription can improve the wheezing of patients inchronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm);3.Jianpi Huatan Pingchuan prescription can improve the ACT scores of patients with chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm);4.Jianpi Huatan Pingchuan prescription can reduce the level of serum VEGF in patients with chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm);5.Jianpi Huatan Pingchuan prescription is safe and effective in treating chronic persistent bronchial asthma(syndrome of deficiency of lung and spleen qi and obstruction of phlegm).