Clinical Observation Of Cizao Anshen Decoction Combined With Estazolam In Treating Insomnia Of The Disharmony Between The Heart And Kidney

Objective: To evaluate the clinical efficacy of Cizao Anshen Decoction combined with estazolam in treating insomnia of the disharmony between the heart and kidney by observing the changes of sleep quality,daytime sleepiness and Traditional Chinese medicine(TCM)syndrome score of insomnia patients of the disharmony between the heart and kidney,and to provide a new idea for TCM treatment of insomnia.Methods: This study was randomized controlled.Taking the patients with insomnia of the disharmony between the heart and kidney as the research object,99 outpatients were selected according to the diagnosis and inclusion criteria,and finally 95 patients were included.The research object was divided into three groups by random grouping: traditional Chinese medicine group,western medicine group and combined group.The traditional Chinese medicine group was given Cizao Anshen Decoction,the western medicine group was given estazolam,and the combined group was given Cizao Anshen Decoction and estazolam.Seven days were a course of treatment,a total of four courses,and the whole course of medication was guaranteed.The Pittsburgh Sleep Quality Index(PSQI),Epworth Sleepiness Scale(ESS),TCM syndrome scoring table and safety indicators were used to evaluate the clinical efficacy and safety.The evaluation was conducted at the first visit and at the second and fourth weeks of treatment.TCM syndrome integral scale,PSQI scale and ESS scale were used as evaluation criteria.In this paper,excel software is used for data input,and SPSS 21.0 data analysis software is used for statistical analysis of relevant data,with P<0.05 as the significance standard.Results: 1.Comparison of baseline data before treatment: It mainly includes the comparison of general baseline data such as age,gender,TCM syndrome score,PSQI scale,ESS scale,etc.of the three groups before treatment(P>0.05),with no significant difference and comparability.2.Efficacy evaluation:(1)TCM syndrome efficacy: The total effective rate of the traditional Chinese medicine group was 90.6%,the total effective rate of the western medicine group was 53.1%,and the total effective rate of the combined group was 96.8%.After chi square test,there was a statistical difference in the total effective rate among the three groups(P<0.05).The efficacy between the three groups was analyzed by Kruskal Wallis H non parametric rank sum test,and there was a statistical difference(P<0.05),and the combined group had the best clinical efficacy.(2)PSQI: After treatment,the total effective rate of the Chinese medicine group was 68.8%,the Western medicine group was 75.0%,and the combined group was 93.5%.According to the chi square test,there was a statistical difference in the total effective rate among the three groups(P<0.05).The efficacy between the three groups was analyzed using Kruskal Wallis H non parametric rank sum test,and there was a statistical difference(P<0.05).The combined group had the best clinical efficacy.(3)ESS: After treatment,the total effective rate of the Chinese medicine group was 68.8%,the Western medicine group was 59.4%,and the combined group was 93.5%.According to the chi square test,there was a statistical difference in the total effective rate among the three groups(P<0.05).The efficacy between the three groups was analyzed by Kruskal Wallis H non parametric rank sum test,and there was a statistical difference(P<0.05),and the combined group had the best clinical efficacy.Conclusion: The clinical efficacy of Cizao Anshen Decoction plus or minus combination with estazolam in improving PSQI and ESS scores of patients with insomnia of the disharmony between the heart and kidney is better than that of estazolam alone and Cizao Anshen Decoction alone,but the efficacy of the combination group and Cizao Anshen Decoction alone in improving the score of TCM syndromes is more than 90%,both of which are better than that of estazolam alone,and no obvious toxic and side effects have been observed.To sum up,it is concluded that compared with the single use of estazolam and Cizao Anshen Decoction,the combined use of drugs has a more significant effect on improving sleep quality,daytime sleepiness,and TCM syndrome performance.