| Objectives Through clinical case-control study,by comparing the differences of general data,blood pressure,liver function,renal function,electrolyte,blood lipid,blood sugar,islet function,insulin resistance index(HOMA-IR),BMD of each part and 25(OH)D level between middle-aged and elderly T2 DM patients with abdominal obesity and those with non abdominal obesity,and the relationship of various indexes and T2 DM complicated with abdominal obesity are analyzed,which could be favorable for the clinical guidance for active weight management of T2 DM patients with abdominal obesity and then reduce the risks of metabolic diseases and osteoporosis.Methods A total of 126 T2 DM patients were selected from the outpatient department of endocrinology and ward of our hospital from November 2020 to November 2021.According to the diagnostic criteria of abdominal obesity,66 patients with abdominal obesity were selected as the case group,and 60 patients with non-abdominal obesity were selected as the control group.Personal data of all patients were collected,and the history of present illness,past history,family history,the duration and and treatments of T2 DM,and special medication history were inquired.Comprehensive physical examinations were conducted for all patients,including blood pressure and waist circumference(WC)were measured.The liver function,kidney function,electrolytes,blood lipid,blood glucose,islet function,glycated hemoglobin,25(OH)D and other indicators were tested in laboratory,and the HOMA-IR was calculated and the results were compared between groups.BMD levels of lumbar L1-L4,left femoral neck and right forearm were measured by DXA method for all patients.The above mentioned contents were sorted into Excel database,and SPSS25.0 software was used for statistical analysis and processing of all data.Results 1 There were no statistically significant differences of gender,smoking history,drinking history,age,T2 DM course,ALP,TC,LDL,HDL,APOa,APOb,Cr,UA,FPG,2h PG,FCP,2h CP,HAb1 c,L1-L4 and the BMD level of right forearm between the two groups(P>0.05),which means that these factors are comparable between groups.There were statistically significant differences of systolic blood pressure,diastolic blood pressure,ALT,AST,TG,FINS and HOMA-IR between the two groups(P<0.05),indicating that these factors were poorly comparable between the two groups.2 The results of univariate analysis showed that the BMD and 25(OH)D levels of left femoral neck in the case group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05),indicating that the BMD of left femoral neck and the level of 25(OH)D in T2 DM patients with abdominal obesity were decreased.3 Taking T2 DM combined with abdominal obesity as the dependent variable,the above factors(systolic blood pressure,diastolic blood pressure,ALT,AST,TG,FINS,HOMA-IR)and the BMD of left femoral neck,25(OH)D were selected as independent variables for binary Logistic regression analysis,and after correcting for each potential confounding factor,the BMD of left femoral neck and 25(OH)D were found to be associated with T2DM combined with abdominal obesity(P<0.05),the BMD of left femoral neck and serum 25(OH)D levels decreased in patients with T2 DM combined with abdominal obesity,especially the left femoral neck BMD.Conclusions 1 Middle-aged and elderly T2 DM combined with abdominal obesity is associated with the left femoral neck BMD,and the left femoral neck BMD is decreased.2 Middle-aged and elderly T2 DM combined with abdominal obesity is related with the level of serum 25(OH)D,and the level of serum 25(OH)D is decreased.Figure0;Table9;Reference 113... |
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