Construction And Application Of Tcm Clinical Efficacy Evaluation Index Database

Objective:1.Taking unstable angina as a demonstration disease,integrate clinical research literature resources,construct an initial index collection,standardize the expression of index terms,try to build a database of TCM clinical efficacy evaluation indicators,provide a convenient way to select standardized indicators in the design of clinical research protocols,and promote the transformation and maximum utilization of TCM clinical research results.2.A clinical study to evaluate the efficacy of Modified Gualou Xiebai Banxia Decoction on the TCM syndrome score and fibrinogen in unstable angina pectoris and Phlegm and blood stasis syndrome of coronary heart disease.Methods:1.A retrospective literature study was carried out by searching seven databases,namely,Zhiwang,Wanfang,Wipu,Sino Med,Web of Science,Pubmed,and the cochrane library,and adopting an annual sampling method to find clinical studies on TCM treatment of unstable angina published in core journals,extracting the basic information of clinical efficacy evaluation indexes,including index names,measurement tools,measurement methods,and efficacy criteria,etc.The indexes were manually normalized and subjected to frequency statistics.Applying Access 2021 database software,we designed the TCM clinical efficacy evaluation index database fields,established data tables and inter-table relationships,covering disease information,primary index information,secondary index information,and literature information.Establish multi-conditional queries to meet different query requirements,improve the form structure and functions,and enter the collated data of the TCM clinical efficacy evaluation indexes of unstable angina into the database in order according to the frequency statistics after collation.2.A total of 85 inpatients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1,2021 to December31,2022 with unstable angina pectoris and Phlegm and blood stasis syndrome as the first diagnosis were selected and randomly distributed into treatment group(43 cases)and control group(42 cases).The control group was treated with conventional Western medicine,and the treatment group was treated with Modified Gualou Xiebai Banxia Decoction,and the treatment period was 2 week.Use Excel software to make the "Unstable Angina Pectoris,Sputum and Stasis Mutual Evidence Case Collection Form" to record the basic information of patients.SPSS 22 software was used for statistical analysis,and the TCM syndrome score and FIB level were selected from the database as evaluation indicators to Access the efficacy of Modified Gualou Xiebai Banxia Decoction on unstable angina pectoris and Phlegm and blood stasis syndrome of coronary heart disease.Results:1.Through retrospective literature analysis,more than 160 kinds of indicators and related index information were extracted,and the database of clinical efficacy evaluation indexes of TCM was constructed after standardized processing,and the database of TCM clinical efficacy evaluation indicators was initially established after debugging the functions of database forms,data modification and login query modules.2.After treatment,the single symptom scores of chest pain,chest tightness,palpitation,shortness of breath,fatigue and TCM syndrome scores of the two groups were lower than before treatment(P<0.05),and the reduction degree of the treatment group was greater than that of the control group(P<0.05).The level of FIB in both groups decreased after treatment,but there was no statistical difference between the two groups(P>0.05).Conclusions:1.In view of the problems of many types and differences in TCM clinical efficacy evaluation indicators,in order to make full use of the index information and realize the standardization and scientificization of TCM clinical research,it is necessary to build a database of TCM clinical efficacy evaluation indicators.The classification of indicators according to the primary indicator framework(TCM evidence indicators,symptom and sign indicators,physical and chemical examination indicators,quality of life indicators,endpoint indicators,economic assessment,safety events,and other indicators)is more conducive to the management and selection of indicators.Access database is suitable for the construction of TCM clinical efficacy evaluation index database,and the method of building database with unstable angina as a demonstration disease can be applied to other diseases.2.Compared with conventional Western medicine,Modified Gualou Xiebai Banxia Decoction in the treatment of UA syndrome of Phlegm and blood stasis has curative advantages in improving the symptoms of chest pain,chest tightness,palpitation,shortness of breath,fatigue,but may not have obvious advantages in the reduction of FIB level compared with Western medicine alone.