| Purpose:Through the clinical study of the unstable angina pectoris with phlegm and blood stasis syndrome,the clinical efficacy and safety of the scattered and Tongmai method on the unstable angina pectoris of the type of coronary heart disease with phlegm and blood stasis are verified,and new theories,new ideas and new methods are provided for the prevention and treatment of clinical coronary heart disease.Methods:This study used prospective,randomized,controlled clinical observation.72 patients with unstable angina pectoris who met the inclusion criteria were randomly divided into treatment group and control group,36 cases in each group.The control group was given the standardized treatment of Western medicine,such as antiplatelet and lipid stabilizing plaque,and the treatment group was treated with traditional Chinese medicine "Sanjie Tong Mai Fang" on the basis of conventional treatment for 12 weeks.The curative effect of TCM syndrome,TCM syndrome score,angina pectoris,the quality of life,electrocardiogram and the rate of nitroglycerin reduction were observed,and 6 were carried out.Follow up was performed to observe the recurrence rate of angina pectoris and the incidence of cardiovascular events.Results:A total of 72 patients were included in this study.The treatment group and the control group were 36 cases respectively.Due to the patient’s own reasons,3 cases were lost,including 1 cases in the treatment group and 2 cases in the control group.The final number of cases was 69 cases,35 cases in the treatment group and 34 cases in the control group.1.the general condition and vital signs of the two groups were compared.There was no difference in P>0.05 between the two groups.2.the curative effect of TCM syndrome: the curative effect of TCM syndrome in the two groups was improved before and after treatment.The total effective rate of the treatment group was 85.71% and the control group was 67.65%.There was a significant difference between the groups(P<0.05).The total scores of TCM syndromes in the two groups before and after treatment were statistically significant(P<0.05).The difference between the two groups was better than thatof the control group at fourth weeks,8 weeks and 12 weeks,respectively.There was a significant difference between the two groups(P<0.05).3.patients’ quality of life: the quality of life of the two groups was improved before and after treatment.There was no significant difference between the two groups before the treatment of Seattle angina pectoris Survey(P>0.05).The 5 spatial dimensions of the patients were significantly increased after the treatment,and the treatment group was in the condition of angina pectoris,angina pectoris stability and treatment satisfaction.It was better than the control group(P<0.05).4.the curative effect of angina pectoris: the curative effect of angina pectoris before and after treatment were improved in the two groups,the total effective rate of the treatment group was 68.57%,the total effective rate of the control group was 55.88%,the total effective rate of the treatment group was higher than that of the control group,and there was no significant difference between the groups(P>0.05).The difference of angina score between the two groups before and after treatment was statistically significant(P<0.05).Comparison between the two groups,8 weeks after treatment and after treatment,the treatment group was better than the control group,there was a significant difference between the two groups(P<0.05).5.electrocardiogram effect: two groups of angina pectoris effect were improved before and after treatment,the total effective rate of the electrocardiogram treatment group was 62.86%,the total effective rate of the control group was 44.12%,and there was no significant difference between the groups(P>0.05).6.the reduction rate of nitroglycerin: the curative effect of angina pectoris before and after treatment in two groups was improved,the rate of nitroglycerin treatment was 85.71%,and the control group was 58.81%.The total effective rate of the treatment group was higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).7.during the 6 month follow-up of patients,the recurrence rate of angina pectoris in the two groups was lower than that in the previous group,and the treatment group was more pronounced(P<0.05).At the same time,no cardiovascular events such as myocardial infarction and sudden death were found in the two groups.8.two groups of patients before and after treatment safety indicators were no abnormalities,no adverse reactions.Conclusion:Through the clinical study of unstable angina pectoris with phlegm and stasis syndrome,the clinical efficacy and safety of Sanjie Tongmai Recipe on patients with unstable angina pectoris with phlegm and blood stasis type were verified.It could reduce the score of TCM syndrome,improve the clinical symptoms,improve the quality of life,improve the effect of angina pectoris,electrocardiogram and the effect of electrocardiogram.The stopping rate of nitroglycerin can reduce the recurrence probability of angina pectoris and block the pathway of disease deterioration. |
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