Effects Of Soothing Liver,Relieving Depression And Dredging Collaterals On Pain,Quality Of Life And Inflammatory Index Of Ankylosing Spondylitis

Objective: By observing the clinical efficacy of the treatment of ankylosing spondylitis by soothing the liver,relieving depression and dredging collaterals combined with thalidomide tablets and cecoxib capsules,it provides a new method for the treatment of this disease.Content: The changes of safety indexes and efficacy indexes before and after treatment were recorded and analyzed,and the differences between soothing the liver,relieving depression and dredging collaterals combined with thalidomide tablets and celecoxib capsules and only thalidomide tablets and celecoxib capsules in the treatment of ankylosing spondylitis were analyzed,so as to evaluate the clinical efficacy of soothing the liver,relieving depression and dredging collaterals.Methods: From January 2022 to December 2022,64 patients who met the inclusion criteria were selected from the Department of Rheumatology of Rizhao Traditional Chinese Medicine Hospital,and stochastic divided into 32 cases in the experimental group and 32 cases in the blank group.The experimental group was given oral thalidomide tablets,celeoxib capsules and self-designed Dalv No.1 prescription.The blank group was treated with oral thalidomide tablets and celecoxib capsules.Each group was treated for 12 weeks.Finger-ground distance,Schober test,VAS grade,PGA grade,BASDAI grade,BASFI grade,ASQoL grade,SAS grade,ESR,CRP,TCM syndrome grade before and after treatment were recorded.The compliance rate of ASAS20,TCM syndrome score,efficacy index of anxiety state and safety index were evaluated and analyzed,and the data were statistically analyzed.Result:1.64 patients meeting the criteria were included,and 4 fell off.60 patients completed the curative effect observation,with a shedding rate of 6.25%.Among them,1 person withdrew from the observation due to self-addition of other drugs,and 3 people withdrew from the observation due to poor compliance,did not take medicine on time and did not complete the course of treatment.2.There was no distinct imparity in gender,age,course of disease,Clinical symptom grade(VAS,PGA,BASDAI,BASFI,ASQoL,SAS,TCM syndrome grade),clinical sign grade(finger-ground distance,Schober test),laboratory indicators(ESR,CRP)between the two groups(P>0.05),which was comparable.3.The above scores decreased in both groups after treatment,the treatment group did better,with remarkable difference(P<0.05).According to the ASAS20,the total effective rate of the two groups was 93.33% in the treatment group and 73.33% in the control group,and the treatment group did better(P<0.05).4.After treatment,the SAS score decreased in both groups with noteworthy difference(P<0.05),and the treatment group did better(P<0.05).5.After treatment,TCM syndrome scores of both groups were decreased,the treatment group did better(P<0.05).The total effective rate of the experimental group and the blank group were 96.67% and 76.67%,with remarkable difference(P<0.05).6.Two patients in the experimental group had inappetence,and five patients in the blank group had abdominal distension and acid reflux in the stomach,which returned to normal after symptomatic treatment.Both groups were safe(P>0.05).Conclusion: The results of this study showed that the combination of soothing liver and relieving depression and dredging collaterals with thalidomide tablets and crecoxib capsules can effectively improve clinical signs and symptoms,lower inflammation index,relieve anxiety and boost the quality of life of patients with AS.The effect is better than treatment with thalidomide tablets and celecoxib capsules alone,and the safety is good in the treatment process.It provides a new method for the treatment of AS in traditional Chinese medicine,and is worthy of clinical promotion.