Analysis Of Serum Eosinophil Level In Patients With Chronic Obstructive Pulmonary Disease In Acute Exacerbation And Stable Stage And Its Influencing Factors

OBJECTIVE It is reported that the level of eosinophils(EOS)has a significant correlation with COPD patients.In this study,we got access of the level of serum EOS in COPD patients with increased serum acute exeabation period and clinically stable period and the same data in healthy people.Also,we made a comparison about factors which is associated with serum eosinophils.Method We randomly selected 200 healthy people and 301 patients who were admitted in hospital.Define group A as COPD patients who were in acute exacerbation phase,and group B as COPD patients who were in their clinical stable phase and group C as healthy people.Make a test of blood cell analysis of three groups.Using the SPSS 17.0 software as a tool to make a respective normal test of the data.Results Among them,40.6% of patients in group A got a serum blood eosinophil percentage of 2% or higher,and 38.8% in group B while group C was 52.8%.The EOS and EOS% of the 3 groups were tested by nonparametric independent Wilcoxon test,and found no statistical difference(P>0.05).Meanwhile make a rescreen of group A and group B,nonparametric independent Wilcoxon test were taken and found a significant difference in EOS,EOS% groups(p=0.00,p=0.00).The EOS% of the blood was divided into the value of two categories and found the gender,BMI and smoking history were related to the serum EOS% through Logistic regression analysis.Conclusion: The level of serum EOS in patients with COPD is lower than that in normal subjects but with no signifance.There were no significant difference between the acute exacerbation stage and clinical stable phase in serum EOS level.ICS has certain influence on EOS and EOS%.Sex,BMI,Age,weight and smoking history were related to serum EOS%.