Clinical Observation Of Medicine-Separated Moxibustion Combined With Quadruple Therapy Inthe Treatment Of HP-Related Chronic Gastritis

Objective:In this study,medicine-separated moxibustion combined with quadruple therapy and western medicine quadruple therapy were used to treat patients with chronic gastritis associated with Helicobacter pylori(Helicobacterpylori-associatedgastritis,HPAG)of damp-heat type of spleen and stomach,in order to evaluate the clinical efficacy of external therapy of traditional Chinese medicine combined with western medicine,and to provide new ideas and methods for the treatment of HPAG.Methods:60 patients with spleen-stomach damp-heat type HPAG were randomly divided into observation group(n=30)and control group(n=30).13C urea breath test was performed before treatment,4 weeks after treatment and 3 months after treatment.The eradication rate and recurrence rate of HP and the changes of TCM symptom evaluation scale in the two groups were observed,and the curative effects of clinical syndromes in the two groups were evaluated.Results:1.Baseline data:There was no significant difference in age,course of disease and sex between the two groups before treatment(P>0.05).2.HP eradication rate:The eradication rate of quadruple therapy group was 81.48%,and that of medicine-separated moxibustion combined with quadruple therapy group was 89.29%.The eradication rate of medicine-separated moxibustion combined with quadruple therapy group was higher than that of quadruple therapy group,and the difference was not statistically significant(P>0.05).3.HP recurrence rate:Three months after the completion of treatment,the recurrence rate of quadruple therapy group was 27.27%,and that of medicine-separated moxibustion combined with quadruple therapy group was 4%.The recurrence rate of quadruple therapy group was higher than that of medicine-separated moxibustion combined with quadruple therapy group,and the difference was statistically significant(P<0.05).4.TCM symptom scores:Compared within the group,the total scores of TCM symptoms in the quadruple therapy group and medicine-separated moxibustion combined with quadruple therapy group were significantly lower than those before treatment(P<0.01).The total score of TCM symptoms in the medicine-separated moxibustion combined with quadruple therapy group was significantly lower than that in the quadruple therapy group(P<0.05).In the intra-group comparison,the scores of individual TCM symptoms in the quadruple therapy group and medicine-separated moxibustion combined with quadruple therapy group were significantly lower than those before treatment(P<0.05).In the aspects of epigastric pain,heavy body sleepiness and halitosis,the improvement of medicine-separated moxibustion combined with quadruple therapy group was significantly better than that of the control group(P<0.01).5.Evaluation of the curative effect of TCM syndrome:After treatment,the effective rate of the control group was 74.07%,and that of the treatment group was 89.29%,the difference was statistically significant(P<0.05).Conclusion:Medicine-separated moxibustion combined with quadruple therapy is more effective than quadruple therapy in the treatment of HPAG of damp-heat type of spleen and stomach,which can better alleviate the clinical symptoms of patients as a whole and strengthen the long-term effect of HP eradication.