Clinical Study Of Huoxue Jiedu Kaiyu Therapy In The Treatment Of Patients With The Combination Of Stasis-toxin-stagnation After PCI

Objective:The clinical study was conducted to evaluate the clinical efficacy and safety of HuangJinShuangShenJiaWei Granules,a traditional Chinese medicine prescription under the guidance of Huoxue Jiedu Kaiyu Therapy on patients with stasis-toxin-stagnation intercombination after PCI,providing scientific basis for the treatment of traditional Chinese medicine in patients with coronary heart disease after PCI.Method:According to the inclusion and exclusion criteria of coronary heart disease after PCI(stasis-toxin-stagnation interjunction type),50 patients who met the requirements and were admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 2021 to April 2022 were selected by random double-blind control method,and the two groups were divided into treatment group and control group with 25 cases each.The treatment group was given Western medicine basic treatment+HuangJinShuangShenJiaWei Granules,and the control group was given Western Medicine basic treatment+HuangJinShuangShenJiaWei Granules simulation(the effective ingredient was 1/20 of HuangJinShuangShenJiaWei Granules).The treatment course of both groups was 12 weeks.TCM syndrome score,Seattle Angina Pectoris Scale score,Hamilton Anxiety Scale score,Hamilton Depression Scale score,blood routine,liver and kidney function and other related safety indicators of the two groups were collected before and after treatment.The scoring scale evaluation was conducted by a third party who had no interest with the researchers.SPSS 26.0 software was used for statistical analysis of the collected data.Results:1.Baseline data:There were 1 case in the control group and 1 case in the treatment group due to loss of follow-up,and the final number of completed cases was 48 cases.There were 24 cases in the control group,including 19 male patients and 5 female patients;There were 24 patients in the treatment group,including 19 males and 5 females.Before treatment,there was no significant difference between the two groups in gender,age,combined risk factors,course of disease,stent implantation,combined drug use and other baseline data(p>0.05),which was comparable.2.TCM syndrome scores:there was no statistically significant difference in TCM syndrome scores between the two groups before treatment(p>0.05),indicating comparability.After treatment,TCM syndrome scores of both groups decreased,and there were significant differences in the scores of both groups(p<0.05).3.Effective rate of TCM syndrome:after treatment,the effective rate of the treatment group was 75%,and that of the control group was 41.6%.There was a statistical difference between the two groups(p<0.05),and the treatment group was better than the control group.4.Hamilton Anxiety Scale score:There was no significant difference in Hamilton anxiety Scale score between the two groups before treatment(p>0.05),indicating comparability.After treatment,there were significant differences in Hamilton anxiety scale before and after treatment between the two groups(p<0.05).After treatment,there were statistically significant differences in scores between the two groups(p<0.05),and the treatment group was better than the control group.5.Hamilton Depression Scale score:There was no significant difference in Hamilton depression scale score between the two groups before treatment(p>0.05),which was comparable.After treatment,there were significant differences in Hamilton depression scale before and after treatment between the two groups(p<0.05).After treatment,there were statistical differences in scores between the two groups(p<0.05),and the treatment group was better than the control group.6.Seattle Angina Questionnaire:There were no statistically significant differences between the two groups in five aspects of physical limitation,angina stability,angina frequency,disease perception,and treatment satisfaction before treatment(p>0.05),indicating comparability.After treatment,the five scores of the two groups were improved,and there were significant differences in the comparison before and after the two groups(p<0.05).In terms of angina stability and angina frequency,there were statistical differences between the treatment group and the control group after treatment(p<0.05),and the treatment group was better than the control group.There were no statistically significant differences between the treatment group and the control group in the degree of physical limitation,disease perception,and treatment satisfaction after treatment(p>0.05).7.Safety evaluation:No significant adverse reactions were observed in the two groups during treatment,and no abnormalities were observed in blood routine,liver and kidney function and other safety indicators.Conclusion:Under the guidance of Huoxue Jiedu Kaiyu Therapy,the traditional Chinese medicine HuangJinShuangShenJiaWei Granules has certain clinical efficacy and good safety in the treatment of patients with stasis-toxin-stagnation interjunction after PCI.This treatment method is worthy of further research and clinical application.