Epidemiology And Clinical Characteristics Of Mycoplasma Pneumoniae Pneumonia In Children

Objectives:To study the epidemic and clinical characteristics of mycoplasma pneumoni ae pneumonia(MPP)in children,so as to provide basis for the prevention and treatment of cli nical MPP and the early prediction of severe mycoplasma pneumoniae pneumonia(SMPP).Methods:The clinical data of 690 hospitalized children with MPP included in the standa rd from January 2018 to December 2019 in the Second Hospital of Shandong University were selected by retrospective analysis,including age,gender,time of onset,clinical manifestation s such as cough,wheezing,fever,dyspnea,etc.,and auxiliary examination of C-reactive protei n(CRP),erythrocyte sedimentation rate(ESR),procalcitonin(PCT),serum alanine aminotrans ferase(ALT),creatine kinase isoenzyme(CK-MB),The humoral immunity(IgA,IgG,IgM),D-dimer,imaging performance and other indicators were used to compare the changes of rele vant indicators in different age groups,and the changes of relevant indicators in the severe gro up and the non severe group in the same age group.The statistically different indicators betwe en the severe and non severe groups were substituted into the Logistic regression equation to c alculate,analyze the factors affecting the severity of children,and comprehensively analyze th e epidemiological and clinical characteristics of MPP.Results:(1)There was no significant difference between male and female patients with MPP(P>0.05).(2)Among the hospitalized children with MPP,the incidence rate of 0-3 years old is higher,accounting for 53.77%,followed by 3-7 years old,accounting for 33.19%,and t he incidence rate of 7-14 years old is the lowest,accounting for 13.04%,with a statistically si gnificant difference(P<0.05).(3)Most MPP occurred in winter,followed by spring,and the d ifference was statistically significant(P<0.05).(4)There were statistical differences in the inc idence of fever,cough and wheezing in MPP children of different age groups(P<0.05).The school-age children were mainly affected by high fever and ultra-high fever,while the infants were mainly affected by moderate fever and low fever,but the incidence of cough and wheezi ng in infants was higher than that in older children.(5)CRP,PCT,ESR,IgM,IgG,IgA,CKMB,ALT,D-dimer in different age groups were significantly different and statistically signifi cant(P<0.05).The younger the age was,the higher the inflammatory index was.The greater t he impact on humoral immunity,the more prone to myocardial damage,liver function damag e,hypercoagulable state and other complications.(6)There were significant differences in CR P,PCT,ESR,IgM,IgG,IgA,CK-MB,ALT,D-dimer between the severe group and the non s evere group(P<0.05).The indexes in the critical group were significantly higher than those in the non-critical group.(7)The statistical differences between the severe group and the non se vere group were brought into the Logistic regression equation for analysis.It was found that C RP,PCT,IgM,IgG,IgA,D-dimer were statistically significant(P<0.05),suggesting that CRP,PCT,IgM,IgG,IgA,D-dimer were all related risk factors affecting the severity of children.Conclusions:1.MPP occurs mostly in children aged 0-3 years,and it is more likely to oc cur in winter.2.MPP children in early school age have a higher incidence of cough,and the fe ver is mainly high fever and ultra-high fever,while infants have a higher incidence of wheezi ng,and the fever is mainly moderate fever and low fever.3.The younger the children with M PP or the more severe the disease,the more obvious the inflammatory reaction,the greater the influence on humoral immunity,and the more prone to related complications.4.CRP,PCT,I gM,IgG,IgA and D-dimer contribute to the early prediction of SMPP.