Clinical Study Of Yangyin Huoxue Recipe On Primary Sjogren’s Syndrome Of Yin Deficiency And Blood Dryness Type And Its Effect On Th17/Treg

Objective: To explore the changes of salivary flow rate,tear flow rate,Sj?gren’s Syndrome Patient Reported Index(EULAR SS Patient Reported Index,ESSPRI),TCM syndrome scores,laboratory indexes and safety indexes in the two groups of patients before and after treatment.The clinical efficacy and safety of Yangyin Huoxue Recipe combined with hydroxychloroquine sulfate in the treatment of primary Sj?gren’s syndrome due to yin deficiency and blood dryness,and its pathogenesis was discussed for the first time.Methods: A total of 52 patients with TCM syndrome of primary Sj?gren’s syndrome of Yin deficiency and blood dryness type were selected and randomly divided into a treatment group and a control group,with 26 cases in each group..The treatment group was given Yangyin Huoxue prescription and hydroxychloroquine sulfate,and the control group was given hydroxychloroquine sulfate.ESSPRI score,salivary flow rate,tear flow rate,TCM syndrome score,laboratory indicators(T helper cell 17,Th17),regulatory T cells were observed and recorded before treatment and after 12 weeks of treatment respectively.(Regulatory T cell,Treg),Th17/Treg ratio and inflammatory indexes ESR,C-reactive protein and safety indexes,and the data were statistically analyzed.Results: During the course of treatment,there were no dropout or exclusion of cases in the treatment group and the control group,and a total of 52 cases(26 cases in each group)completed the clinical study.Before treatment,the gender,age,course of disease,salivary flow rate,tear flow rate,Sj?gren’s syndrome patient-reported index score,TCM syndrome score,laboratory indicators Th17,Treg,Th17/Treg ratio and inflammatory indicators ESR,C Reactive protein and safety indexes were not significantly different(P>0.05).1.Comparison of disease curative effect and TCM syndrome curative effect: After treatment,the effective rate of disease curative effect and TCM syndrome curative effect in the treatment group(92.30%,88.46%)were higher than those in the control group(65.40%,57.70%)(P<0.05).2.Comparison of tear flow rate and saliva flow rate: The tear flow rate and saliva flow rate of the two groups of patients after treatment were significantly improved(P<0.01),and the treatment group was significantly better than the control group(P<0.01).3.Comparison of TCM syndrome scores: The TCM syndrome scores of the two groups of patients after treatment were significantly lower than those before treatment(P<0.01),and the treatment group was significantly better than the control group(P<0.01).4.Comparison of Sj?gren’s Syndrome Patient Report Index(ESSPRI)scores: The ESSPRI scores of the two groups of patients after treatment were lower than before(P<0.01),and the treatment group was significantly better than the control group(P<0.01).5.Comparison of laboratory indicators: After treatment,the inflammatory indicators ESR,C-reactive protein,Th17 cell level,and Th17/Treg ratio in the two groups were all decreased(P<0.05,P<0.01),and the Treg cell level was increased.Highly significant(P<0.01),and the treatment group was better than the control group(P<0.05,P<0.01).6.Comparison of safety indicators: There were no adverse reactions in the two groups during the treatment process,and no significant changes in blood routine,liver and kidney function occurred in the two groups.in conclusion:The clinical efficacy of Yangyin Huoxue Recipe combined with hydroxychloroquine sulfate on patients with primary Sj?gren’s syndrome of Yin deficiency and blood dryness type is definite,and it can effectively improve the saliva flow rate,tear flow rate,TCM syndrome score and ESSPRI score of patients,and can reduce Yin deficiency and blood dryness.The expression levels of erythrocyte sedimentation rate,C-reactive protein and Th17 in peripheral blood in patients with primary Sj?gren syndrome of deficiency-blood dryness type increased Treg expression and decreased Th17/Treg ratio.