Correlation Analysis Of Inflammatory Factors And Bone Mineral Density In Postmenopausal Patients With Type 2 Diabetes Mellitus

Objective:To clarify whether there is an association between serum inflammatory factor levels and bone mineral density in postmenopausal type 2 diabetic patients and to explore the correlation between serum inflammatory factor levels and bone mineral density.Methods:1.Patients who met the inclusion criteria were selected and divided into osteoporosis group osteopenia group and normal group according to bone mineral density level.Osteoporosis group: T value(27)-2.5,osteopenia group:-2.5 ￡T value ￡-1.0,and normal group: T value(29)-1.0.2.Collect general information of patients including time of menopause,height,weight,etc.The biochemical indexes such as fasting blood glucose(FBG),low density lipoprotein(LDL),creatinine(SCr),and urea nitrogen(BUN)were detected by automatic biochemical analyzer.3.The levels of tumor necrosis factor(TNF-α),interleukin 6(IL-6),interleukin 1β(IL-1β),interleukin 18(IL-18),and lipocalin(ADP)were measured using enzyme-linked immunosorbent assay(ELISIA),and the Pearson correlation coefficient was applied to correlate bone mineral density with inflammatory factors.4.Logistic regression analysis was performed for inflammatory factors(CRP,TNF-α,IL-6),systolic blood pressure,serum calcium,total cholesterol(TC)and triglyceride(TG).Results:1.A total of 141 patients were included in this study,including osteoporosis group(n=47),osteopenia group(n=46),and normal group(n=48).Basic data showed that there was no statistical significance in age,menopause time,BMI,FBG and other general information among the three groups(P>0.05).2.The CRP level was significantly higher in the osteoporosis group than in the osteopenia group and the normal group(P<0.05),whereas there was no significant difference between the osteopenia group and the normal group(P>0.05).The TNF-α level in osteoporosis group was higher than that in osteopenia group and the normal group(P<0.05),and there was no significant increase in TNF-α levels in the osteopenia group and the normal group(P>0.05).The increased of IL-6 level in osteoporosis group was more significant than that in osteopenia group and the normal group(P<0.05),but there was no significant increase in IL-6 level in reduced the osteopenia group and normal group(P>0.05).While the changes in IL-1β,IL-18 and ADP were not statistically significant(P>0.05).3.Correlation analysis of BMD with serum inflammatory factors CRP,IL-1β,IL-18,and ADP showed that BMD was negatively correlated with CRP,TNF-α,and IL-6(r values of-0.207,-0.616,and-0.729,respectively,P<0.05),while there was no significant correlation with IL-1β,IL-18,and ADP(P>0.05).4.CRP,TNF-α,and IL-6 have predictive value for bone mineral density in postmenopausal patients with type 2 diabetes mellitus combined with osteoporosis.5.Multivariate analysis suggested CRP(OR=1.020,P=0.040),IL-6(OR=1.042,P=0.029),TNF-α(OR=1.003,P=0.008),TG(OR=1.519,P=0.002)and systolic blood pressure(OR=1.238,P=0.026)were independent risk factors for postmenopausal T2 DM patients with osteoporosis.Conclusions:1.Inflammatory factors are correlated with bone mineral density in postmenopausal T2 DM patients with osteoporosis.2.The level of CRP,TNF-α,and IL-6 levels were negatively correlated with BMD levels in postmenopausal patients with T2 DM combined with osteoporosis.3.The level of CRP,TNF-α and IL-6 can be used as independent risk factor s to predict changes in BMD in postmenopausal T2 DM combined with osteoporosi s and provide guidance for disease treatment.