| Objective:This study was conducted to observe and analyze the effects of the treatment method of milli-fire needle zanzhi combined with local percussion on various clinical indicators and the incidence of postherpetic neuralgia in patients with acute herpes zoster,to verify the clinical efficacy of this treatment method in treating patients with acute herpes zoster,and to determine its safety,with the aim of providing a safe and effective treatment plan for the clinical treatment of acute herpes zoster.Methods:The study population was obtained from 90 patients with acute phase herpes zoster who attended the outpatient clinics of the Department of Acupuncture and Moxibustion and the Department of Dermatology at the Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine between October 2020 and December 2021 and met the criteria for nadir,and were randomly grouped according to a 1:1 ratio using computerized statistical software,with 45 cases each in the observation group and the control group.Control group: oral administration of valacyclovir hydrochloride tablets(1g/time,three times a day)and mecobalamin tablets(0.5mg/time,three times a day)for 2 weeks.Observation group: On the basis of oral western medicine,milli-fire needle zanzhi combined with local percutaneous treatment was given,according to the relevant operation standard,once a day for the first three days,and once every other day afterwards,for two weeks.The data of pain index,rash healing index,comprehensive score of herpes zoster and the quality of life and sleep quality of patients were recorded before treatment,at 3d,7d and 14 d after treatment,and a one-month follow-up was done after treatment to record the incidence of postherpetic neuralgia,and the adverse events that occurred during the trial were also recorded in detail,and the final collected data results and information were summarized and statistically analyzed.Results:1 A total of 90 patients with acute herpes zoster were included in this study,84 cases were actually completed,42 in the observation group and 42 in the control group,and a total of 6 patients failed to complete clinical observation,with a loss rate of 6.67%.2 Baseline data: including general conditions such as gender,age,disease location,disease duration,as well as VAS score,herpes zoster composite score,quality of life score(EQ-VAS)and sleep quality score(PSQI)before treatment,etc.The two groups were statistically compared,and the differences were not statistically significant(P>0.05),and the groups were flush and comparable.3 Pain evaluation index: VAS scores before treatment and VAS scores at 3d,7d and 14 d after treatment in both groups were analyzed by repeated-measures ANOVA,and the differences were statistically significant(P < 0.05)in the two comparisons at each time point within the group,and the scores at each time point after treatment were lower than those at the previous time point;the VAS scores at each time point were statistically compared between the two groups after treatment.The differences were all statistically significant(P < 0.05),and the VAS scores of the observation group were lower compared with the control group.4 Lesion healing index: The time to stop blistering,crusting and debridement of herpes lesions in both groups were statistically different(P < 0.05),and the time to stop blistering,crusting and debridement were shorter in the observation group compared with the control group.5 Comparison of herpes zoster composite scores: After treatment,the composite herpes zoster scores of patients in both groups were lower than those before treatment(P < 0.01),and the intergroup comparison between the two groups after treatment suggested that the difference between the composite scores of the two groups was statistically significant(P <0.05),and the scores of the observation group were lower than those of the control group.6 Quality of life and sleep quality assessment: before and after treatment,the differences in EQ-VAS scores and PSQI scores before and after intra-group comparison between the two groups were statistically significant(P < 0.01),and EQ-VAS was higher and PSQI was lower than before treatment;the inter-group comparison after treatment suggested that the differences in EQ-VAS and PSQI scores between the two groups were statistically significant(P < 0.01).The EQ-VAS was higher and PSQI was lower in the observation group.7 PHN incidence rate: 4 cases of PHN occurred in 42 patients in the observation group,with an incidence rate of 9.52%;11 cases in the control group,with an incidence rate of26.19%,and the difference was statistically significant by chi-square test(P < 0.05).8 Comparison of efficacy determination: the total effective rate of the observation group was 95.24%,with 9 cases cured,19 cases with significant effect,12 cases effective,and 2cases invalid,while the total effective rate of the control group was 83.33%,with 3 cases cured,12 cases with significant effect,20 cases effective,and 7 cases invalid,and the difference was statistically significant by statistical comparison between the two groups(P <0.01).Conclusion:1 Both treatments were able to relieve patients’ neuralgia symptoms,promote healing of skin lesions,as well as improve patients’ comprehensive symptoms and signs.2 The combination of milli-fire needle zanzhi with local percutaneous pricking was faster and more obvious for patients’ pain relief compared with oral western medicine treatment alone,which not only shortened the course of the disease but also reduced the incidence of neuralgia after one month of treatment,and its overall efficiency was higher.3 The treatment method of milli-fire acupuncture combined with local percutaneous acupuncture can improve the patients’ quality of life level and improve the problem of sleep disorder,and there are no adverse events during the treatment period,and the safety is higher. |
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