Analysis Of The Incidence And Influencing Factors Of Cholelithiasis In The Urban Physical Examination Population Of Baise City,Guangxi

Objective: Investigate the incidence of cholelithiasis among people undergoing physical examination in urban of Baise City,Guangxi,analyze the pathogenesis and risk factors of cholelithiasis.To explore the correlation between blood biochemical indicators such as total protein,total bilirubin,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,γ-glutamyl transpeptidase,fasting plasma glucose,blood lipids and cholelithiasis.Methods: Using the convenience sampling method,three large hospitals in Baise City,Guangxi,were selected.According to the continuous enrollment criteria,5294 medical examiners who participated in health examinations in the three hospitals from November2020 to June 2021 were included as the research objects.According to the results of abdominal B-ultrasound,the research subjects were divided into a case group(with cholelithiasis)and a control group(without cholelithiasis).The general data such as gender,age,occupation,adress,BMI,SBP,DBP,and blood biochemical indicators such as TP,TBIL,ALT,AST,ALP,GGT,FPG,TC,TG,HDL-C,LDL-C,VLDL-C of the two groups were collected.SPSS 25.0 was used for statistical analysis.The incidence of disease was expressed as a percentage(%),and Chi-square test was used to analyze the differences in the incidence of cholelithiasis among different genders,age groups,occupations,and t-test and MannWhitney U test were used to compared the levels of BMI,fasting plasma glucose,and blood lipid between case group and the control group.Binary logistic regression was used to analyze the factors affecting the occurrence of cholelithiasis in the study subjects.According to the test level of α=0.05.Results:(1)A total of 734 people with cholelithiasis were diagnosed in this survey,and the incidence of cholelithiasis was 13.9%;among them,391 cases of gallstones,a detection rate of 7.4%;316 cases of intrahepatic bile duct stones,a detection rate of 6.0%;27 cases of extrahepatic bile duct stones,the detection rate was 0.5%.(2)Logistic regression analysis showed that age(OR=1.028,P<0.001),BMI(OR=1.480,P<0.001),TG(OR=0.901,P=0.006),HDL-C(OR=0.635,P=0.014),ALP(OR=1.005,P=0.022),SBP(OR=1.027,P<0.001)and fatty liver(OR=1.301,P=0.040)were closely related to gallstones,and BMI(OR=1.322,P<0.001),AST(OR=0.986,P=0.043)and fatty liver(OR=2.929,P<0.001)were closely related to hepatolithiasis.Conclusions: The overall detection rate of cholelithiasis in Baise City,Guangxi Province was slightly higher than the national average.The elderly,self-employed,obesity,hypertension,abnormal liver function,dyslipidemia,and fatty liver are high risk factors for the occurrence of gallstones;low education level,abnormal liver function,the level of fasting plasma glucose,obesity and fatty liver are high-risk factors for the occurrence of intrahepatic bile duct stones.