Analysis Of The Detection Rate And Related Risk Factors Of Cholelithiasis In 300 Patients With Liver Cirrhosis

Objective By retrospective analysis of the difference between the detection rate of cholelithiasis(cholelithiasis and cholecystectomy)between 300 patients with cirrhosis and healthy people,the detection rate of cholelithiasis in patients with cirrhosis was studied.The correlation of liver cirrhosis with cholelithiasis and the risk factors of cholelithiasis in liver cirrhosis are discussed,which provide theoretical basis for the management of clinical.Methods Select 300 inpatients with cirrhosis caused by various causes in the General Hospital of Ningxia Medical University between November 2016 and December 2016,which can be divided into two groups: cirrhosis cholelithiasis group(105 cases)composed by cholelithiasis in patients with liver cirrhosis,liver cirrhosis without cholelithiasis group(195 cases)composed of liver cirrhosis without cholelithiasis patients.At the same time,a normal control group(289 cases)was established for the health check-up population of the General Hospital of Ningxia Medical University in the same period.Analysis of differences in the detection rate of cholelithiasis between patients with cirrhosis and healthy physical examination.To observe the difference between general condition(sex,age),etiology(hepatitis B,hepatitis C,cholestasis,etc.)and complications(infection,hepatic encephalopathy,liver cancer,etc.),Child-Pugh classification,serological test,abdominal B-ultrasound,CT,MRI and other imaging examinations in cirrhosis patients combined with cholelithiasis and without cholelithiasis,univariate statistical analysis may lead to risk factors for cholelithiasis.Explore the risk factors for cholelithiasis in patients with cirrhosis.The above data are all analyzed using SPSS 24.0.Results In this study,the detection rate of cholelithiasis in patients with liver cirrhosis was 35%(105/300),and the detection rate of cholelithiasis in healthy population was only 6.92%(20/289);The detection rate of cholelithiasis in cirrhotic patients was significantly higher than that in healthy subjects(p=0.000<0.05).The sex ratio of patients with liver cirrhosis male: female = 2.26:1,distributed in(21-82)years old.Among them,there was no statistical difference in the detection rate of cholelithiasis(P=0.074>0.05).In terms of age,the average age of patients with cirrhosis complicated with cholelithiasis(58.7±10.6)was significantly higher than that of patients with cirrhosis without cholelithiasis(55.2±10.8,p=0.008<0.05).In the Child classification,there were 115 patients in grade A,143 in grade B,and 41 in grade C.Among them,the detection rate of cholelithiasis in Child C and Child B patients was significantly higher than that in Child A patients(46.3%,39.2%)(26.1%),and the difference was statistically significant(P=0.025<0.05).In the etiological comparison,the detection rate of cholelithiasis in patients with HCV cirrhosis(76.9%)was significantly higher than that in patients with hepatitis B cirrhosis(29.6%)and primary biliary cirrhosis(40%,P=0.001<0.05).Among the serological markers,univariate analysis showed that there was a significant difference between albumin,total bilirubin,indirect bilirubin,and non-infected cholelithiasis in patients with cirrhosis complicated with cholelithiasis(P<0.05);There was no significant difference in blood lipids index(P>0.05).Among the complications,the detection rate of gallstone disease in patients with liver cirrhosis complicated with hepatic encephalopathy(64.7%)was significantly higher than that in patients with liver cirrhosis without hepatic encephalopathy(33.2%,P=0.008<0.05).The detection rate of cholelithiasis in cirrhotic patients(46.2%)with co-infection(intestinal infections,urinary tract infections,pulmonary infections,biliary tract infections,and intra-abdominal infections)was significantly higher than that in patients without cirrhosis(29.1%,P= 0.003<0.05).Conclusion 1.The detection rate of cholelithiasis in patients with liver cirrhosis was significantly higher than that of healthy people.2.Age,liver function Child-Pugh classification,hepatitis C cirrhosis,primary biliary cirrhosis,hepatic encephalopathy,infection,bilirubin,albumin as a risk factor associated with cirrhosis with cholelithiasis.