Exploration Of TCM Syndrome Distribution In Patients With Colorectal Cancer Cain Dased On Cluster Analysis

Objective:Based on cluster analysis,the distribution of TCM syndromes of colorectal cancer pain was explored to analyze the pain degree and dimension of different syndromes,so as to provide early intervention for cancer pain treatment.Methods:Patients with cancer pain of colorectal cancer which visited Fujian Provincial People’s Hospital from January 2021 to January 2022,were investigated by cross-sectional study method,a total of 140 questionnaires were distributed in this study,and 135 valid questionnaires were collected.Basic information and database of TCM four-diagnosis information were established,cluster analysis of TCM four-diagnosis information was conducted,TCM syndrome distribution law of colorectal cancer pain was explored,and the pain degree and dimension of different syndromes were analyzed by correlation.Result:1.The majority of patients with colorectal cancer pain were mild pain(1-3 Points),and the score of pain dimension was daily work > emotion > daily life > sleep > life interest >others > walking ability.2.The following five TCM syndromes are classified which colorectal cancer pain TCM four diagnostic information by clustering analyse:(1)syndrome of phlegm dampness and difficulty: oppressive pain;the body type is fat,dizziness,expectoration,body weigt,drowsiness,fullness in the stomach,sallow complexion or pale white complexion,constipation,be worried,anorexia,thick fur,greasy fur,smooth pulse,sunken pulse.(2)syndrome of yin deficiency of liver and kidney: aching pain,persistent pain,pain has no obvious preference,lassitude in loin and legs,restless fever hands and feet,swarthy complexion,perspire during sleep,dry mouth,dry eye,red lip color,abdominal pain,lack of vitality,red tongue,yellow fur,thready rapid Pulse.(3)syndrome of qi-stagnancy and blood stasis: swelling pain,scurrying pain,stabbing pain,pain refusing to pressure or the more pressure more wracking,depression or irritable,want to gargle but don’t want to swallow,gloomy complexion,cinerous complexion,bluish purple tongue,stringy pulse.(4)Syndrome of yang deficie and cold coagulation: angina,crymodynia,thirsty and fond of hot drinks,cold fits,spontaneous sweating,numbness,tastelessness,without desire for food,dark urine,teeth-marked tongue,tense pulse.(5)syndrome of qi and blood deficiency: dull pain,pressure-relieved pain or the more pressure pain more relief,lacking in strength,lip color light white,the body type is emaciation,astringent,abdominal distension,anorexia,thin sloppy stool,irritable,sleep but easy awaken,pale red tongue,pale tongue,deep thready or thready pulse.3.TCM syndromes of patients with colorectal cancer pain were classified into 5syndromes,which were arranged in descending order: the syndrome of qi stagnation and blood stasis(41.5%),the syndrome of deficiency of qi and blood(17.8%),the syndrome of yang deficiency and coagulated cold(14.8%),the syndrome of stagnation of phlegm-dampness(13.3%),the syndrome of liver-kidney yin deficiency(12.6%).There was no significant difference in gender,age stratification,pain course,location of pain and pain type distribution among all syndromes(P>0.05).There were statistically significant differences in pain degree among all syndromes(P<0.05).In terms of NRS score,there were statistically significant differences between the syndrome of liver-kidney yin deficiency,the syndrome of qi stagnation and blood stasis(P=0.007)and the syndrome of deficiency of qi and blood(P=0.006).The NRS score of the syndrome of liver-kidney yin deficiency was higher than the latter two syndromes.There was statistically significant difference in the pain dimension among all syndromes(P<0.05),and there was no statistically significant difference in the influence of pain on daily life,walking ability,daily work,other people and life interest among all syndromes in the past 24 hours(P>0.05).But the pain syndrome in the past 24 hours effect to the mood,sleep affect the difference was statistically significant(P<0.05),the pain to the mood affect the score in the past 24 hours,there are statistical differences between the syndrome of deficiency of qi and blood and the syndrome of stagnation of phlegm-dampness(P=0.003),the syndrome of yang deficiency and coagulated cold(P=0.013)and the syndrome of deficiency of qi and blood affect mood is more obvious.In terms of the impact score of pain on sleep in the past 24 hours,there was statistical difference between the syndrome of liver-kidney yin deficiency,the syndrome of stagnation of phlegm-dampness(P=0.009)and the syndrome of qi stagnation and blood stasis(P=0.022),and the syndrome of liver-kidney yin deficiency had more serious impact on sleep.Conclusion:1.The majority of patients with colorectal cancer pain were mild pain.Pain dimension score: daily work > mood > daily life > sleep > life interests > others > walking ability.2.Through cluster analysis the TCM syndromes of patients with colorectal cancer pain were classified into 5 syndromes,which were arranged in descending order: the syndrome of qi stagnation and blood stasis、the syndrome of deficiency of qi and blood、the syndrome of yang deficiency and coagulated cold、the syndrome of stagnation of phlegm-dampness、the syndrome of liver-kidney yin deficiency.3.In patients with cancer pain of colorectal cancer,the syndrome of qi stagnation and blood stasis syndrome is the most common.which mild and moderate pain was the majority.The syndrome of deficiency of qi and blood was the next,and mild pain was more common,which had more obvious effect on emotion.Thirdly,the syndrome of yang deficiency and coagulated cold、the syndrome of stagnation of phlegm-dampness,both are more common with with moderate pain.Finally,patients with liver-kidney yin deficiency syndrome have a higher risk of severe pain,which has a greater impact on sleep.