Gastric Cancer Syndrome Characteristics Of Clinical And Experimental Research And Traditional Chinese Medicine For Gastric Cancer Neovascular Formation

stomach cancer(SC), a kind of malignant tumor in gastric epithelium, a most common kind of malignant tumor in whole world include china.The death rate of SC is 23.02% of all malignant tumor in chinais the most high one.SC have four period signed by the depth of its transference and infiltration.The reseach have such item: 1 find out the distribute characteristic of SC and i~s syndrome in Tradition Chinese Medicine(TCM) and the mechanisms characteristic of SC different periods,definite the most common syndrome main component and offer degree of each syndrome;2 detected the change of gene expression table about two syndromes s isoforms by gene chip technique,detected the correlation between NEGF expression in SC tissue and syndrome of TCM by tissue immunochemistry;3 based the several anticancer herb effected VEGF ,confirmed the relation between the generate of VEGF and syndrome of TCM ,screen a herb(yadanzi) that could restrain the newly born vascularization of tumor,which would guide to select suitable herb in clinical.The result showed: 1 SC mechanisms is very complicated, deficiency of the vital principle and excess of the pathogenic factor are mutually cause and effect,main mechanisms is different in the develop proess of different disease, the distribution of syndrome is different also.At deficiency of the vital principle aspect, deficient Qi is the essential mechanisms, especially deficient appetite-qi run through all disease process of SC. Qi deficient is more serious$7in the third and fourth period of SC. At excess of the pathogenic factor aspect, cancer poison is essential, the emergence of cancer poison, the key point of SC generation, caused by effect accumulation of negative factor in vivo and vitro in long time.stagnant blood and phlegm-damp, which is pathologic output and new etiological factor,cause SC deterioration. 2 the distribution regularity of SC TCM syndrome showed that internal stasis of pathogenic heat was primary in eariler period~. knot of stagnant blood and phlegm in metaphase and deficient Qi with stagnant blood in final period. TCM syndrome was concerned with the change of gene express table, gene express of syndrome which was a isoforms of internal stasis of pathogenic heat showed that the vital principle is not deficient and have the ability of defend, but the isoforms of deficient Qi with stagnant blood not so ,its gene function was wait for more study. The vascularization of tumor had close relation with cancer poison and deficient Qi, and deteriorate the stagnant blood.So th~ blood vascular density of tumor is possible to become a objective index of stagnant blood. 3 the experiment which several kind herb affect the blood vessel of tumor was carried out, the result showed that the dissipating heat and detoxifying herb had the most powerful effect on the blood vessel of tumor, had directly anticancer function and restrain function on tumor vascularization,is first selection in internal stasis of pathogenic heat;the herb of eliminating the stagnant and activating the blood ,like a twin blade sword ,could kill the tumor cell to result the necrosis of tumor body and cause tumor vascularization to create a good condition for the growth and transference of tumor.So the key is correctly use of the herb of eliminating the stagnant and activating the blood in anticancer treatment.