Diuretic Effect Of Xuanfei Tongyang Lishui Method On Edema In Children With Primary Nephrotic Syndrome

Objective: To observe the diuretic and detumescence effects of Xuanfei Tongyang Lishui method(Mahuang Fuzi Xixin Decoction and Wuling Powder)in the treatment of edema in children with primary nephrotic syndrome,and to evaluate its efficacy and safety.Methods: Sixty children with edematous stage of primary nephrotic syndrome who met the inclusion criteria were selected and divided into observation group and control group,with 30 cases in each group.The control group was treated with western medicine,and the basic Mahuang Fuzi Asarum Decoction and Wuling Powder of the control group were observed for 1 week.The degree of edema,24-hour urine volume,abdominal perimeter,body weight,urine protein,serum albumin,liver and kidney function were compared between the two groups before and after treatment.Results:1.There was no significant difference in general data(age,gender,degree of edema),TCM,24-hour urine volume,body weight,abdominal circumference and laboratory parameters before treatment between the two groups(P>0.05),with comparability.2.In terms of overall clinical efficacy,the effective rate was 96.5% in the observation group and 88.9% in the control group,and the difference was statistically significant(P<0.05).The effective rate of the observation group was better than that of the control group.3.The total effective rate of TCM was 93.1% in the observation group and88.9% in the control group,and the difference was statistically significant(P<0.01).The total score of TCM was 8.69±3.82 points in the observation group and 10±2.79 points in the control group before treatment,and1.10±1.88 points in the observation group and 3.33±2.54 points in the control group after treatment.The total score of the two groups were significantly decreased,and the observation group was superior to the control group(P <0.01).In terms of each single score of TCM,the single scores(edema,cough,sputum,nasal congestion,runny nose,and pharyngeal redness)of the two groups decreased after treatment,and the observation group was superior to the control group,and the differences were statistically significant(P< 0.05).4.In terms of edema improvement,the degree of edema in both groups was significantly improved after treatment,and the observation group was superior to the control group(P<0.05).The 24-hour urine volume was759.45±492.91 ml in the observation group and 568.28±326.69 ml in the control group before treatment,1589.83±703.04 ml in the observation group and 1197.02±432.04 ml in the control group after treatment.The 24-hour urine volume was significantly increased in both groups after treatment(P<0.01),but there was no significant difference between the two groups(P>0.05).Before treatment,body weight was 29.41±13.57 cm in observation group,31.82±18.32 cm in control group,25.19±11.94 cm in observation group and 30.10±17.24 cm in control group.After treatment,body weight decreased in both groups(P<0.01),and there was no significant difference between the two groups(P>0.05).Before treatment,abdominal perimeter was 60.66±11.61 cm in observation group,60±13.71 cm in control group,56.61±9.68 cm in control group and 58.31±13.43 cm in control group.After treatment,abdominal perimeter decreased in both groups(P<0.01),but the difference between the two groups had no statistical significance(P>0.05).5.Laboratory parameters,after treatment,the two groups of urinary protein were significantly negative,and the observation group reduced urinary protein better than the control group(P<0.05).Serum albumin was18.92±8.23 g/L in observation group,15.99±3.45 g/L in control group,22.11±11.83 g/L in observation group and 20.2±6.53 g/L in control group before treatment.Both groups could increase serum albumin(P<0.01),but there was no significant difference between the two groups(P>0.05).6.There was no significant change in safety indicators before and after treatment in the two groups(P<0.05),and no adverse reactions occurred during treatment.Conclusions:1.Xuanfei Tongyang Lishui method can significantly reduce the degree of edema in children with primary nephrotic syndrome,increase urine volume,reduce urine protein,improve clinical efficacy.2.Xuanfei Tongyang Lishui method can significantly improve the symptoms of edema fengshui beat syndrome in children with primary nephrotic syndrome.3.The Xuanfei Tongyang Lishui method had good safety and no adverse reactions occurred.