| ObjectiveTo observe and record the changes in tumor volume under ultrasound-guided radiofrequency ablation,and to compare the intraoperative indexes,cancer cell residual rate,tumor recurrence rate,etc.indexes of ultrasound-guided radiofrequency ablation and surgical resection for the treatment of papillary thyroid microcarcinoma,and analyze two treatment options Short-term and long-term efficacy.MethodsFrom January 2013 to December 2017,74 patients with thyroid micro papillary carcinoma who were admitted to the First Affiliated Hospital of Zhengzhou University were studied by ultrasonography and no obvious lymph node metastasis was found.According to the order of admission,patients were divided into experimental group(37 cases)and control group(37 cases)according to the operation mode,the control group was given conventional surgical resection,and the study group was treated with ultrasound-guided radiofrequency ablation.Record the intraoperative indicators of the patient,follow up the patient for 1 to 3 years after the operation,record the volume of the lesion before treatment and 1 month,3 months,6 months,and 12 months after treatment,and record and observe the residual and recurrence of cancer cells in the patient.Results(1)The operation time,intraoperative blood loss,incision length,postoperative pain disappearance time and treatment cost of the study group were significantly lower than those of the control group,and the difference was statistically significant(P>0.05).(2)Before treatment,the tumor volume of the patients in the study group was(0.14±0.04)cm3,the tumor volume after 1 month of treatment was(0.27±0.13)cm3,and the tumor volume after 3 months of treatment was(0.11±0.05)cm3,and the tumor volume was(0.11±0.05)cm3 after 6 months of treatment.The tumor volume after treatment was(0.07±0.04)cm3,the tumor volume after 12 months of treatment was(0.01±0.01)cm3,and the final tumor volume reduction rate was(93.05±3.27)%.The difference before and after treatment was statistically significant(F=74.472,P<0.001).(3)There was no significant difference in the residual rate of cancer cells and the rate of tumor recurrence between the study group and the control group(P>0.05).Conclusion(1)Ultrasound-guided radiofrequency therapy has short operation time and little damage to normal tissues around tumors,because it is minimally invasive and has little trauma to the body and low treatment cost.It can be standardized under the condition of strict control of indications;(2)Ultrasound-guided radiofrequency ablation in the treatment of papillary thyroid microcarcinoma can effectively reduce the size of the patient’s lesions and has a better curative effect;(3)The residual rate of cancer focus and the rate of tumor recurrence of radiofrequency ablation in the treatment of papillary thyroid microcarcinoma are equivalent to traditional resection.ObjectiveTo compare the safty of ultrasound-guided radiofrequency ablation and the traditional surgery for patients who were diagnosed with thyroid micropapillary carcinoma,oxidative stress-related factors,and thyroid function-related factors of patients before and after the treatment of ultrasound-guided radiofrequency ablation and traditional surgery,the effects on the physiological functions and the complication rate of the two treatments.MethodsThe patients were selected as above,The levels of malondialdehyde(MDA),lipid peroxide(LPO),superoxide dismutase(SOD),free triiodothyronine(FT3),free thyroid hormone(FT4)and thyroid stimulating hormone(TSH)in 2 groups were detected before and after treatment.The postoperative complications of the two groups of patients were recorded and analyzed.Results(1)There was no significant difference in serum FT3,FT4,and TSH levels between the two groups before treatment(P>0.05).After treatment,there was no significant difference in FT3,FT4,and TSH levels in the study group compared with the treatment cost(P>0.05)In the control group,postoperative TSH was significantly increased,FT3 and FT4 were significantly decreased,and the difference was statistically significant(P<0.05).The TSH level of the study group was significantly lower than that of the control group,and FT3 and FT4 were significantly higher than the control group,the difference was statistically significant(P<0.05).(2)There was no significant difference in the levels of MDA,LPO,and SOD between the two groups before treatment(P>0.05).After treatment,the levels of MDA and SOD in the study group were significantly lower than those in the control group,and the LPO levels were significantly higher than those in the control group.The difference was statistically significant Significance(P<0.05).(3)There was no statistically significant difference in the incidence of complications between the study group and the control group(P>0.05).ConclusionCompared with resection,ultrasound guided radiofrequency ablation has little effect on postoperative inflammatory response and little effect on postoperative oxidative stress.Meantime,it can also preserve the thyroid function without increasing the complications. |
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