| Objective:In this project,through the use of traditional Chinese medicine Xu Li’s prescription for pulmonary nodules to treat pulmonary nodules,observe the changes in the largest diameter of pulmonary nodules,clinical malignancy probability,TCM syndrome integrals and other relevant indicators before and after treatment,objectively evaluate the clinical efficacy of Professor Xu Li’s prescription for pulmonary nodules in the treatment of pulmonary nodules,discuss the law of dynamic changes of pulmonary nodules,and provide reference and new ideas for the treatment of pulmonary nodules in Traditional Chinese medicine.Method:From November 2020 to February 2022,80 patients with pulmonary nodules who met the acceptance and exclusion criteria of this subject and voluntarily participated in the outpatient department of oncology and general internal medicine of Jiangsu Hospital of traditional Chinese medicine were included.They were randomly divided into two groups with 40 cases in each group.The treatment group was given oral Xu Li’s prescription for pulmonary nodules,while the control group was only followed up regularly without intervention.The course of treatment was 6 months.The changes of relevant indexes such as the maximum diameter of pulmonary nodules,clinical malignant probability and TCM syndrome score were observed before and after treatment.Through data processing and analysis,the clinical efficacy and mechanism of xulifeijie formula in the treatment of pulmonary nodules were preliminarily evaluated.Results:In the end,a total of 78 patients were fully involved in this study,the control group and the treatment group were 39 cases.The sex,age distribution,malignant tumor history,smoking history,number of pulmonary nodules,the largest diameter of pulmonary nodules,the clinical malignancy probability of pulmonary nodules and other information of the two groups of patients were analyzed before treatment,and the P was>0.05,suggesting no statistical significance and comparable.After a 6-month study,the conclusions are as follows:(1)After investigating 78 patients with pulmonary nodules in this study,it can be seen that in terms of gender distribution,the number of women is more than the number of men,and male-female ratio is about 1:2.7;in terms of age distribution,the number of patients in the middle age of 46-69 years old is the largest,and patients in the middle age segment account for 77%of the patients included in the project;in terms of the number of nodules,multiple nodules are more than isolated nodules,and the ratio is about 3.6:1;in terms of the number of smokers,there are more patients with no smoking history than patients with a history of smoking,and patients with no smoking history account for 64%of the patients included in the study.There were significant differences in the distribution of smokers between men and women,with male smokers accounting for 62%of male patients and female smokers accounting for 16%of female patients.(2)Analysis on the change of pulmonary nodule size and clinical efficacy:from the change of pulmonary nodule size,there was significant difference in the maximum diameter of pulmonary nodule before and after treatment in the treatment group(P<0.05).The maximum diameter of pulmonary nodule was significantly smaller than that before treatment in the control group(P>0.05).The maximum diameter of pulmonary nodule had no significant change compared with that before treatment.The maximum diameter of pulmonary nodule in the treatment group was significantly smaller than that in the control group.In terms of clinical efficacy,the total effective rate of the treatment group was 30.7%,and that of the control group was 7.7%,P<0.01,suggesting that there was a significant difference.The clinical efficacy of the treatment group was better than that of the control group.(3)Analysis of changes in clinical malignant probability of pulmonary nodules:comparison within the group:there was no significant difference in clinical malignant probability of pulmonary nodules between the treatment group and the control group before and after treatment(P>0.05).The clinical malignant probability of pulmonary nodules in the treatment group decreased significantly before and after treatment;The clinical malignant probability of pulmonary nodules in the control group decreased slightly before and after treatment;Comparison between groups:the treatment group has a greater reduction in the probability of clinical malignancy than the control group,indicating that this study has significant advantages in reducing the risk of clinical malignancy of pulmonary nodules.(4)Analysis of TCM syndrome score and TCM clinical efficacy of patients with pulmonary nodules:from the change of TCM syndrome score of patients with pulmonary nodules,the TCM syndrome score of pulmonary nodules before and after treatment in the treatment group and the control group was statistically significant(P<0.01).The TCM syndrome score of pulmonary nodules in the treatment group was significantly lower than that before treatment,and the TCM syndrome score of pulmonary nodules in the control group was slightly higher than that before treatment.From the clinical efficacy of traditional Chinese medicine:the effective rate of the treatment group was 64.1%,and that of the control group was 2.6%.It can be seen that the curative effect of the treatment group in the improvement of TCM syndrome is significantly better than that of the control group.Conclusions:Xu Li’s prescription for pulmonary nodules can effectively reduce the size of the pulmonary nodules,control the growth of the pulmonary nodules,and reduce the probability of clinical malignancy of the pulmonary nodules,and improve clinical symptoms,which is worth further research and promotion. |
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