Comparative Study Of Intravenous Tranexamic Acid Combined With Different Drainage Methods In Total Hip Arthroplasty

Purpose: To explore the comparative study of intravenous infusion of tranexamic acid combined with negative pressure and non-negative pressure drainage during total hip arthroplasty on perioperative blood loss and postoperative complications,in order to achieve a more effective and safe reduction in perioperative blood loss in clinical practice The amount of postoperative drainage decision-making provides a reference basis.Method: A total of 80 patients who were admitted to the Department of Orthopedics,People’s Hospital of Guangxi Zhuang Autonomous Region from October 2018 to September 2019 who were planned to undergo initial unilateral total hip replacement were selected.The patients were randomly divided into two groups.Experimental group: intravenous infusion of 1.0g tranexamic acid10 minutes before surgical skin incision,the same dose was given 3 hours later,and postoperative vacuum drainage was adopted;control group: tranexamic acid The method of use is the same as that of the experimental group,with conventional negative pressure drainage after the operation.The drainage tube of the two groups of patients was removed after the drainage volume was less than 50ml/24 h or less than 20ml/8h.Record the preoperative hematocrit value,prothrombin time,hemoglobin value,intraoperative blood loss,postoperative drainage,total hospital stay,extubation time,blood transfusion rate,incidence of DVT and PE,poor wound healing or The incidence of infection.Result: There was no significant difference between the two groups in gender,age,BMI,preoperative Hb,Hct,PT,intraoperative blood loss,etc.(P>0.05).The experimental group was less than the control group in terms of postoperative significant blood loss,total postoperative blood loss and total perioperative blood loss,and the differences were statistically significant(P<0.05).There were no significant differences between the two groups in terms of total hospital stay,incidence of deep vein thrombosis,incidence of infection,and Harris hip score(P>0.05).Conclusion: The combination of intravenous drip of aminocycline and negative pressure drainage can reduce the bleeding rate of total hip replacement without increasing the incidence of complications.