Effect Of Topical Application Of Tranexamic Acid On Perioperative Blood Loss And Safety In Total Hip Arthroplasty

Objective: To study the effect of local application of Tranexamic acid(TXA)on total hip replacement arthroplasty(THA)and safety of total hip replacement arthroplasty(THA).Methods: A total of 63 patients with unilateral THA were enrolled in the Department of Surgery,Chaohu Hospital,Anhui Medical University from November 2014 to February 2017.Divided into two groups,A group of 37 cases,B group of 26 cases.Group A was the experimental group.Intra-articular drainage tube was injected with 2.0 g TXA(dissolved in 10 ml saline)at the end of the surgical dressing.B group as the control group,in the surgical wound after the end of the joint cavity drainage tube into the same amount of saline.The hemoglobin,hematocrit,blood loss,blood transfusion and blood transfusion were compared at 24 h,48 h and 72 h before and after replacement.The fibrinogen,prothrombin time and activated part Coagulation time,lower extremity deep vein ultrasound.Results: The hemoglobin,hematocrit,postoperative blood loss,blood transfusion and blood transfusion were significantly better in group A than group B at 24 h,48 h and 72 h after replacement(P <0.05).(P <0.05).There was no significant difference in fibrinogen,prothrombin time and activated partial thromboplastin time and deep vein thrombosis(DVT)between the two groups before and after replacement.No statistical difference(P> 0.05).Conclusion: The local application of TXA group can significantly reduce the THA perioperative blood loss and do not increase the risk of lower extremity DVT.