Preparation Of NiO/Mn Film And Study On Its Glucose Sensor Characteristics

Diabetes is a non-negligible health problem for people all over the world.For diabetics,daily blood glucose detection has become an indispensable thing,so glucose has become the most common analysis substance,so glucose measurement has great clinical significance.At present,glucose sensor has gradually evolved from the original enzyme glucose sensor to a non-enzyme glucose sensor with low detection limit,high sensitivity,good stability and other advantages.At present,one of the sensitive materials for non-enzymatic glucose sensors is transition metal and its oxides.This kind of materials has become the focus of researchers because of its good electron transfer characteristics,economical and practical price,and simple manufacturing process.In this paper,the nickel oxide film is prepared by electrodeposition on ITO conductive glass material,and the nickel oxide film is modified by manganese doping,so as to obtain a composite film material with better performance.The microstructure of nickel oxide thin films and nickel oxide/Manganese thin films prepared by electrodeposition in ionic liquid system were studied by XRD,SEM,EDS and other testing methods,and the optimal preparation parameters were explored.The electrochemical performance of the films for glucose detection was investigated by cyclic voltammetry and current-time method.Firstly,the technology of electrodeposition of choline chloride-urea ionic liquid to prepare nickel oxide film was investigated.By adjusting the viscosity of ionic liquid,concentration of nickel chloride and deposition potential during electrodeposition,The most suitable technological parameters were investigated and summarized:the volume ratio of anhydrous ethanol to ionic liquid was 2:1,the concentration of nickel chloride was 0.2mol/L and the deposition potential was 3.9V.Secondly,the nickel oxide film after electrodeposition is evaluated and analyzed.The linear range of the glucose sensor was 4～256μmol/L and 312～528μmol/L,and the sensitivity was 496.03μA/(mmol/L·cm2)and 67.59μA/(mmol/L·cm2),respectively.The electrochemical sensor has excellent selectivity,reproducibility and stability,and the detection limit(S/N=3)is 1.00μmol/L.Finally,the electrodeposited nickel oxide thin films were doped with manganese to prepare better composite thin films.Through scanning electron microscopy and energy spectrum testing,it is found that manganese in the film is roughly evenly distributed on the nickel oxide film,and the particle size of the doped NiO film is more uniform.The incorporation of manganese leads to the refinement of agglomeration particles and increases the specific surface area of the film.The linear range of glucose detection was 2.5～250μmol/L and 291.67～491 μmol/L.The detection limit was 0.8μmol/L,and the sensitivity was 1596.38μA/(mmol/L·cm2)and 466.36μA/(mmol/L·cm2)under the condition of 3 times SIGNal-to-noise ratio(S/N=3).Diabetes is a worldwide public health problem,and tens of thousands of diabetics need to test their blood glucose every day,so glucose has become the most common analyte.So the detection of glucose has important clinical significance.So far,the glucose sensor has been developed from the original enzyme glucose sensor to a non-enzyme glucose sensor with high sensitivity,low detection limit and good stability.At present,one of the research hotspots of non-enzymatic glucose sensor sensitive materials is transition metals and their oxides,which have become the focus of researchers because of their excellent electronic transmission properties,low price and simple preparation process.