Analysis Of Complex Firing Activities In The Neuron System

In recent years,issues such as global warming and environmental pollution have become increasingly serious,resulting in a variety of respiratory diseases.Respiratory diseases are often strongly related to respiratory rhythms.Therefore,investigating complex respiratory rhythms through theoretical and experimental studies can aid in the diagnosis and treatment of these diseases.The pre-Botzinger complex is a special region in the mammalian brainstem,within which there is a special type of inspiratory neuron that plays fundamental role in generation and regulation of the respiratory rhythms.Researchers have found that these neurons can produce spontaneous rhythmic firing activities.Firing,mainly divided into spiking and bursting,is a way for neurons to transmit information.There is a type of dendritic mixed bursting(DMB),which can be produced by the sole action of dendrite.In this paper,based on the single neuron model of the pre-Botzinger complex constructed by Park and Rubin,The mode of DMB was investigated,and the effects of different ion conductances on DMB were also studied.The underlying dynamic mechanisms of the DMB were explained and classified using different methodologies including fast-slow decomposition and bifurcation analysis.The paper is divided into five chapters,with the first chapter being the introduction,and the second chapter providing some basic knowledge related to biological neurons.In the third chapter,several special patterns of DMB were discovered based on the single neuron model of the preB(?)tzinger complex and numerical simulations.Unlike the previously reported DMB,some patterns of DMB mentioned in this paper involve three or more periods of dendritic relaxation oscillations in one full periodic cycle.The transition mechanism of DMB patterns was also examined by altering the sodium conductance and persistent sodium conductance.In the fourth chapter,using the same model,the effects of calcium-activated non-specific cation conductance and leak conductance on depolarization block bursting were studied.The final chapter includes our conclusion and discussion of the findings.