Bibliometric Analysis Of Literature On Drug Use Rules Of Acute Cerebral Hemorrhage By Promoting Blood Circulation And Removing Blood Stasis

ObjectiveTo explore the application regularity of Chinese herbs when treating acute cerebral hemorrhage with the function of activating blood circulation and removing blood stasis.MethodsAll literatures on the clinical efficacy of activating blood circulation and removing stasis in the treatment of acute intracerebral hemorrhage collected in CNKI,Wanfang and VIP databases in the past 20 years were searched to obtain literatures that met the standard.Excel software was used to extract prescription information as research data,SPSS 25 was used for statistical analysis of drug use frequency distribution.SPSS 25 was used for cluster analysis between drugs.IBM SPSS Modeler 18 was used for association rule analysis of medication.Results1.68 prescriptions were included in this study,involving a total of 99 Chinese medicines,and the total frequency of drug use reached 606 times.16 herbs were used more than 10 times,and the top 10 herbs in frequency were Ligusticum chuanxiong,Safflower,peach kernel,radix paeoniae,salvia miltiorrhiza,Angelica,Rhubarb,Panax notoginseng,leech and achyranthes bidens.2.Set the minimum support level of 10%,the minimum confidence level of 80%,the maximum of the preceding item is 5,and conduct association rule analysis for drugs.The top 20 herbal drug pairs with high support and high confidence involved 11 Chinese herbs(Peach kernel,safflower,red peony root,Astragalus membranaceus,salvia miltiorrhiza,Angelica,earthworm,Chuanxiong,Caulis spatholobi,Mirabilite,rhubarb),The combination of 3 herbs involves 10 herbs(Peach kernel,safflower,red peony root,Astragalus membranaceus,salvia miltiorrhiza,Angelica,ligusticum chuanxiong,Rhubarb,Achyranthes bidentata,leech,panax notoginseng),The combination of 4 herbs involves 7 herbs(Peach kernel,red flower,peony root,Astragalus,salvia miltiorrhiza,Angelica),The above 3 combinations involved 14 commonly used drug combinations(Peach kernel,safflower,red peony root,Astragalus,salvia miltiorrhiza,Angelica,earthworm,Chuanxiong,Caulis spatholobi,Mirabilite,Rhubarb,Panax notoginseng,Achyranthes bidentata,leeches).Commonly used drug pairs:peach kernel-safflower,red peony root-safflower.Astragalus membranaceus-salvia miltiorrhiza,earthworm-salvia miltiorrhiza,etc.Commonly used combinations of 3 herbs:peony root-red flower-peach kernel,red flower-chuanxiong-peach kernel,peony root-Chuanxiong-red flower,etc.Commonly used combinations of 4 herbs:radix paeoniae paeoniae-red flowerchuanxiong-peach kernel,angelica-Radix paeoniae paeoniae-red flower-peach kernel,etc.3.The four qi of 99 traditional Chinese medicines mainly include warm and cold drugs.Among them,temperature drugs were used 220 times,accounting for 36.30%.The frequency of cold drugs was 217 times,accounting for 35.81%;There were more cold drugs,up to 40,accounting for 40.41%.Only 27 warm drugs were selected,accounting for 27.27%.The five flavors were mainly bitter,sweet and spicy,and the frequency and number of bitter drugs were the highest,accounting for 55.78%and 48.49%,respectively,followed by sweet drugs,followed by spicy drugs.4.The four qi of 99 traditional Chinese medicines mainly include warm and cold drugs.Among them,temperature drugs were used 220 times,accounting for 36.30%.The frequency of cold drugs was 217 times,accounting for 35.81%;There were more cold drugs,up to 40,accounting for 40.40%.Only 27 warm drugs were selected,accounting for 27.27%.The five flavors were mainly bitter,sweet and spicy,and the frequency and number of bitter drugs were the highest,accounting for 55.78%and 48.49%,respectively,followed by sweet drugs,followed by spicy drugs.5.By analyzing the efficacy of 68 prescriptions,The top 4 drugs were promoting blood circulation and removing stasis,tonifying deficiency,calming liver wind and clearing heat,accounting for 39.44%,13.20%,10.07%and 9.57%,respectively.6.Through complex network analysis,it was found that the core drug combinations of activating blood and removing stasis in the treatment of acute cerebral hemorrhage were Ligusticum chuanxiong,Acorus tatarinowii,Trichosanthes trichosanthes,safflower,radix paeoniae,Angelica and peach kernel.7.According to the analysis of the cluster member table,four effective clusters were obtained according to 10 clusters:C1:Acorus tatarinosus,Poria cocos,turmeria turmeria;C2:Peach kernel-safflower-peony root-Angelica;C3:Salvia miltiorrhizaAchyranthes bidentata-Astragalus membranaceus-Earthworm-Caulis spatholobus;C4:Gastrodia elata-Antelope horn-Uncaria-Scutellaria baicalensis According to the pedigree diagram,when the distance was equal to 20,drugs could be divided into 6 clusters,S1:Mirabilite and Magnolia officinalis;S2:Acorus gladiolus.Tuckahoe,tuber,Biliostar,pinellia ternata;S3:Rhubarb,Panax notoginseng,Gastrodia elata,Uncaria,Antelope horn,Scutellaria baicalensis,rehmannia glutinosa,Trichosanthes trichosanthes;S4:Safflower,peach kernel,peony root,Angelica,Earthworm,Suberect spatholobus,Astragalus membranaceus,Salvia miltiorrhiza,Achyranthes bidentata;S5:Ligusticum chuanxiong,leech;S6:radix paeoniae alba.ConclusionAccording to the "Blood leaving the meridians being blood stasis" and" blood stasis causing wind syndrome" at the core of the pathogenesis,the application of data mining methods found that promoting blood circulation to remove blood stasis treatment of acute cerebral hemorrhage of prescription regularity,for clinical Chinese medicine treatment of acute cerebral hemorrhage can simplify the dialectical process,for promoting blood circulation to remove blood stasis method as reference sent the clinical treatment of acute cerebral hemorrhage,to further promote and serve the clinical practice.It also reflects from the side that "stasis" is the core pathogenesis of intracerebral hemorrhage,not the only pathogenesis.It suggests that we should not only pay attention to"stasis",but also consider the damage of "wind","fire","phlegm","deficiency","poison" and other pathogenesis to the brain marrow.Therefore,the treatment of acute cerebral hemorrhage should follow the principle of syndrome differentiation and treatment on the basis of activating blood circulation and removing blood stasis.