Slip Molding For Microparticle On-demand Synthesis

This paper reports on a Slip Chip-based microfluidic molding method for the synthesis of microparticles on-demand(m Pods)with fast and easy loading-slipping-solidification operations,and it does not require pumps,masks,or other axillary fluidic control instruments.This method is based on the relative movement of two microfluidic plates that are in close contact,and the size and shape,even 3D structure of double layers of the microparticles can be accurately controlled by the geometry of the microcavities imprinted on the contacting surfaces of these microfluidic plates.To demonstrate the capability of this method,m Pods of different size and various shapes are presented with photosensitive resin via photo polymerization reaction.Synthesis of two-layer Janus microparticles is also demonstrated by a slip over-molding method.The agarose was used to prove the material selectivity and bioavailability of this method for preparing microparticles.This Slip Chip-based molding method can offer new opportunities for producing customized microparticles with great flexibility for a broad spectrum of applications,including single cell analysis,tissue engineering,drug delivery,and multiplexed biomolecule analysis.At the same time,because of the simple equipment and convenient operation,the method is conducive to the realization of industrialized microparticle production.