Research On Molecular Computation Based On New Type DNA Strand Replacement Catalytic System

Recently,DNA computing developed quickly and attracted lots of attentions from researchers.Compared with electronic computers,DNA computing has incomparable advantages.Through biological systems engineering and molecular information processing,the DNA computing can implement the computing activity as a digital computer.In fact,as the basic operation unit,logic gates in electronic computers constitute all complex operation processes.a variety of new strand replacement model molecular logic gates based on DNAzyme are developed for basic logic operation and a series of molecular circuits.Here,the main operations are repeated DNAzyme digestion and entropy-driven strand displacement.Finally,via the elaborate molecular hybridization designs,a molecular half adder is constructed to perform the unique logic computing operation.Due to the catalytic and amplified functions,the DNAzyme based half adder can respond to the inputs at a rather low concentration.Therefore,the DNAzyme based computing system can be applied to the field as molecular sensing,DNA computing and biosignal processing.