| Objective:To observe the short-term clinical effect of acupoint catgut embedding in fat layer guided by the theory of five circuit phases and six natural factors in the treatment of simple obesity with gastric heat and humidity resistance.Methods:The 70 patients who met the inclusion criteria were randomly divided into the experimental group(acupoints selection guided by the theory of five circuit phases and six natural factors)and the control group(conventional acupoints selected),with 35 cases in each group.After 1 week of baseline evaluation,acupoint cat-embedding therapy was conducted with once a week,4 times for a course of treatment,a total of 2 courses,and the two groups shared a same basic acupoint prescription.Then,the experimental group was matched with Feishu(BL13)double and Juque(CV14)guided by the five circuit phases and six natural factors in 2018,and the control group was combined with Ganshu(BL18)double and Shuifen(CV9)on the basis of commonly used points for weight loss.To observe the improvement of Body Mass Index(BMI),Waist Circumference(WC),Fasting Insulin(FINS),Insulin resistance index(HOMA-IR),Fasting Blood Glucose(FPG),and TCM symptom score after 1 and 2 courses of treatment between those two groups.Results:1.70 patients were enrolled,6 were exfoliated,and 64 completed all the treatment at last.According to the analysis principle of Per Protocol Set(PPS),a total of 64 cases were included in the statistical analysis,and the baseline data were consistent between the groups(P>0.05).2.Main Outcome Mesures:BMI:Comparison within the group:the BMI both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of BMI in the experimental group was better than that in the control group(P<0.05)after the same course of treatment.3.Secondary Outcomes:(1)WC:Comparison within the group:the WC both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of WC in the two groups was similar(P>0.05)after 1 course of treatment,the improvement of the experimental group was better than that of the control group after 2 courses of treatment(P<0.05).(2)FINS:Comparison within the group:the FINS both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of FINS in the experimental group was better than that in the control group(P<0.05)after the same course of treatment.(3)HOMA-IR:Comparison within the group:the HOMA-IR both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of HOMA-IR in the experimental group was better than that in the control group(P<0.05)after the same course of treatment.(4)FPG:Comparison within the group:the FPG both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of FPG in the experimental group was similiar with that in the control group(P<0.05)after the same course of treatment.(5)TCM symptom score:Comparison within the group:the TCM symptom score both in experimental group and control group was better than that before treatment(P<0.05)after 1 and 2 courses of treatment.Compared with other groups,the improvement of TCM symptom score in the experimental group was better than that in the control group(P<0.05)after the same course of treatment.Therapeutic evaluation:1.In the first course,the rate of total effective in the experimental group was 75.76%,and the rate of total effective in the control group was 61.29%,the difference between the two groups was statistically significant after compared with each other(P<0.05).2.At course 2,the rate of total effective in the experimental group was 93.94%,and the rate of total effective in the control group was 80.65%,the difference between the two groups was also statistically significant after compared with each other(P<0.05).Safety evaluation:During the entire study,2 patients in the experimental group had adverse reactions,and 3 patients in the control group had adverse reactions.The incidence of adverse reactions was 6.06%and 9.68%,and there was no difference between the groups(P>0.05),suggesting that both acupoint embedding methods are safe.Conclusion:1.Both the treatment with acupoint embedding in the fat layer guided by the theory of five circuit phases and six natural factors and acupoint embedding in the regular fat layer can effectively improve the BMI,WC,FINS,HOMA-IR,FPG and TCM symptoms score of simple obesity patients with gastric heat and humidity resistance.However,in terms of improving patients' WC,the two treatments were equivalent in 1 course,and the former was better than the latter after 2 courses.2.The improvement of BMI,FINS,HOMA-IR and TCM symptoms score of simple obesity patients with gastric heat and humidity resistance in the acupoint embedding treatment in the fat layer guided by the theory of five circuit phases and six natural factors was more significant than the regular acupoint embedding treatment in the fat layer,but the improvement of FPG was similar in both groups.3.The guidance of five circuit phases and six natural factors in the fat layer acupoint embedding and selecting has certain guiding significance for the clinical treatment of simple obesity with gastric heat and humidity resistance. |
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