Study On TCM Syndromes And Clinical Characteristics Of Sjögren's Syndrome Complicated With Pulmonary Interstitial Lesions

Purpose:By collecting case data on patients with Sjogren's syndrome without pulmonary interstitial lesions and Sjogren's syndrome combined with pulmonary interstitial lesions at the Affiliated Hospital of Liaoning University of Chinese Medicine,to explore the correlation between SS-ILD and TCM syndromes,general conditions,clinical symptoms,serological indicators,and analyze the risk factors and pathogenesis of SS-ILD,so as to provide some theoretical support for early diagnosis SS-ILD.Material and method:1.Collected the clinical data of SS-ILD and SS-NILD patients admitted to the affiliated Hospital of Liaoning University of traditional Chinese Medicine from January 2013 to December 2020.2.Records included the general situation,TCM syndrome,clinical characteristics,serological indicators,chest CT examination results and other data.3.Use SPSS26.0 statistical software to analyze the differences between SS-ILD and SS-NILD groups in general situation,clinical characteristics,laboratory indicators and so on.4.Explores the correlation between SS-ILD and TCM syndrome,general conditions,clinical symptoms,and analyzed the risk factors and pathogenesis of SS-ILDResults:1.Significant probability of five TCM SS with ILD(P<0.01).The incidence of various types is as follows : Dispersion of lung by dryness 4.4%;Yin deficiency heat poison certificate 6.3%;Qi-yin Deficiency Syndrome 56.5%;Yin deficiency blood stasis certificate 15.4%;Liver and kidney Yin deficiency certificate 39.1%.The incidence of ILD of Qi-yin deficiency syndrome was higher than that of lung,yin-deficiency,heat-deficiency,yin-deficiency and blood;The incidence of ILD of liver and kidney Yin deficiency syndrome was higher than that of dry evil lung and Yin deficiency,and the difference had significant statistical significance(P< 0.01);no statistical difference between both groups(P< 0.05).2.The age,course,globulin,ESR,CRP of SS-ILD group were higher than the SS-NILD group(P<0.01).No statistical difference in onset age,sex,smoking history and drinking history(P> 0.05).3.No statistical difference between the SS-ILD group and the SS-NILD group in dry mouth,dry eyes,dry eyes,dry skin,enlarged parotid gland,rampant teeth,Renault phenomenon,joint pain and fatigue(P> 0.05).4.The SS-ILD group of dryness evil invades the lung syndrome in C3 was lower than the SS-NILD group,in CRP was higher than the SS-NILD group,and the difference was statistically significant(P<0.05).5.The SS-ILD group with yin deficiency and heat toxin syndrome in course of disease and globulin were higher than the SS-NILD group,and the difference was statistically significant(P<0.05).6.The SS-ILD group with Yin deficiency and blood stasis syndrome in C3 was lower than SS-NILD,in course of disease,ESR and CRP were higher than the SS-NILD group,and the difference was statistically significant(P<0.05).7.The SS-ILD group with Qi-yin deficiency syndrome in age,course,globulin,ESR and CRP were higher than the SS-NILD group,and the differences was statistically significant((P<0.05).8.The SS-ILD group with liver and kidney yin deficiency syndrome in course of disease,ESR,CRP and RF were higher than the SS-NILD group,and the difference was statistically significant(P<0.05).9.There was no significant difference in other aspects of five TCM syndromes(P>0.05).10.Group SS-ILD cough 38(73.1%)>chest tightness 33(63.5%)>sputum 28(53.8%)>gas shortness24(46.2%)>dyspnea 4(7.7%)> pestle refers to 1(1.9%).Chest CT abnormalities in all SS-ILD patients,mesh shadow 23(44.2%)>ground glass 20(38.5%)>patch shadow19(36.5%)>cord shadow 18(34.6%)>interlobular septal thickening 10(19.2%)> pleural thickening 9(17.3%)>honeycomb shadow 6(11.5%)> traction bronchiectasis 3(5.8%)> pleural downline 2(3.8%).Conclusion:1.Qi Yin two deficiency syndrome and liver and kidney Yin deficiency syndrome are easy to combine with ILD.2.Older,longer course of disease,globulin or ESR or CRP increased significantly are easy to combine with ILD.3.The dryness evil invades the lung syndrome,CRP increased significantly,C3 decreased significantly;Yin deficiency and heat toxin syndrome,long course of disease,globulin increased significantly;Yin deficiency blood stasis,long course of disease,CRP or ESR increased significantly,C3 decreased significantly;Qi-yin deficiency syndrome,old age,long course of disease,globulin or ESR or CRP increased significantly;Liver and kidney yin deficiency syndrome,long course of disease,ESR or CRP or RF increased significantly.4.SS-ILD chest CT is mainly manifested as mesh shadow,ground glass sample,patch shadow,and cable bar shadow.