Connective Tissue Disease Associated Interstitial Lung Disease Study On Syndrome Types Of Traditional Chinese Medicine And Clinical Characteristics

Objective: to summarize the general data of patients with connective tissue disease associated interstitial pulmonary disease,common TCM syndromes,clinical symptoms,high resolution CT imaging features,tumor markers and other clinical features for clinical diagnosis and disease.Prognostic judgment provides ideas.Methods: from February 2017 to February 2018,84 patients with connective tissue disease associated pulmonary diseases who were hospitalized and outpatient in Xinjiang Uygur Autonomous region Hospital of traditional Chinese Medicine were collected,and the clinical symptoms and syndromes of TCM were summarized by questionnaire.Each patient received high-resolution lung CT and tumor marker CEA125,CA153,CA199.Inspection.Result: 1.A total of 84 cases(female: 48)were collected,with an average age of 66.98 ±10.20 years.36 cases of male with an average age of 69.14 ±10.96 years of age,there were 36 cases of CTD in front of ILD and 42.9% of them appeared at the same time as ILD.There were 11 cases of CTD in front of CTD.The proportion of CTD of different types was as follows:among them,35 cases of RA-ILD patients were 41.6p SS-ILD patients,17 cases were 20.2% of AAV-ILD patients,13 cases of AAV-ILD patients were 20.2% of them.The proportion of RA-ILD patients of different types of CTD was: 35 cases of RA-ILD patients were 41.6p SS-ILD patients and 17 cases of them were 20.2% of AAV-ILD patients.There were 11 MCTD-ILD patients with MCTD-ILD and 5 patients with SSc-ILD.There were 3 patients with PMP-DM-ILD,3 with MCTD-ILD,3 patients with MCTD-ILD and 5 patients with SSc-ILD.The distribution of TCM syndromes was as follows: heat and dryness injury in 21 cases,lung yin deficiency in 18 cases,phlegm and turbid obstruction of lung in 13 cases,Qi stagnation and blood stasis in 11 cases,lung qi deficiency and cold in 11 cases,and deficiency of lung and kidney.(3)the proportion of burst sounds in clinical symptoms and signs of 10 patients with both yin and yang damage was the highest,followed by that of CTD-ILD patients.The order was cough,shortness of breath,sputum,joint pain,skin damage,high resolution lung CT findings of 4.CTD-ILD patients with fever: RA-ILD with reticular shadow,honeycomb shadow,The most common p SS-ILD was glass-ground shadow and the most common PM-/ DM-ILD was grid shadow.The most common SSc-ILD was reticular shadow of AAV-ILD,and the most common of honeycomb shadow was glass-grinding shadow.The most common lesions of MCTD-ILD were glass-grinding shadow and six kinds of CTD-ILD lesions were mainly involved in lower lung.The second is the middle lobe of the lung,and the least involved is the upper lung.Ye Jian5.There was no significant difference in CEA between different TCM syndromes(P > 0.05)and there were significant differences in CA125 and CT visual scoring values in CA153CA199 and lung CT,and the deficiency syndrome was higher than that of the positive ones(P < 0.05).Conclusion: 1 more women than men,associated with the incidence of connective tissue disease in women,CTD-ILD patients do not always accompany connective tissue disease systematic performance,so the discovery of ILD,should be routinely screened for CTD;2 Distribution of TCM syndromes of this disease: heat and dryness in 21 cases of lung injury,lung yin deficiency in 18 cases,phlegm and turbid obstruction of lung in 13 cases,Qi stagnation and blood stasis in 11 cases,lung qi deficiency and cold in 10 cases,deficiency of lung and kidney in10 cases,and both yin and yang damage in 10 cases.3 The most common clinical symptoms and signs of CTD-ILD patients were burst sounds,followed by cough,shortness of chest,sputum,joint pain,skin damage and fever,indicating that the respiratory symptoms of clinical CTD-ILD patients were more than those of systemic symptoms.The diagnosis of lung auscultation and burst sound is of great significance,and the clinical diagnosis should pay attention to pulmonary body examination.4 the lung high-resolution CT imaging findings of different CTD-ILD patients were characterized by their specific features,such as: RA-ILD,reticular,honeycomb,and so on.The most common p SS-ILD was glass-ground shadow and the most common PM-/ DM-ILD was grid shadow.The most common SSc-ILD was reticular shadow of AAV-ILD,and the most common of honeycomb shadow was glass-grinding shadow.The most common lesions of MCTD-ILD were glass-grinding shadow and six kinds of CTD-ILD lesions were mainly involved in lower lung.The second was the middle lobe of the lung,and the least involved was the upper lobe of the lung.5 the difference of CT visual evaluation value and tumor markers in different TCM syndromes of CTD-ILD patients was statistically significant,which suggested that the patients of deficiency syndrome group had more serious condition and worse prognosis than those of the positive group.