| Purpose:To explore the change characteristics and influence of dyHDL and endothelial factor in patients with coronary heart disease with abnormal blood lipids and spleen deficiency and phlegm turbidity.Material and method:In the early stage of the trial,the acceptance and discharge standards were formulated,and the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine was used as the clinical research center for the trial.Use enzyme-linked immunosorbent assay method to detect the collected serum,use SPSS software to determine the normal distribution by using the KS method,and use the mean ± standard deviation(±S)for the data of the normal distribution.The dyHDL component and the endothelium The relationship between the factors uses the Pearson correlation analysis method,and the ROC curve is used to predict the subtypes of nitric oxide synthase,ET-1,PON1,ICAM-1,SAA/APOA-I,MPO/PON1,Apo B/Apo A-The diagnostic significance of the I ratio.Results:1.A total of 123 people were recruited in this study,17 people in the healthy group,50 people with coronary heart disease with dyslipidemia of spleen deficiency and phlegm turbidity syndrome,and 56 people with coronary heart disease dyslipidemia without spleen deficiency and phlegm turbidity syndrome.The control group was 56.94±7.92 years old(P<0.01),systolic blood pressure was 136.18±15.67 mm Hg(P<0.05),blood glucose was5.95±0.64 mmol/L(P<0.01),TG was 1.11±0.31 mmol/L(P<0.01),CHOL of 4.32±0.74mmol/L(P<0.01),LDL-C of 1.43±0.17 mmol/L(P<0.01)are lower than those of coronary heart disease with dyslipidemia,spleen deficiency and phlegm turbidity,HDL-C was1.43±0.17 mmol/L(P<0.01)higher than that of coronary heart disease with dyslipidemia,spleen deficiency and phlegm turbidity syndrome group.The age of coronary heart disease with abnormal blood lipids and non-spleen deficiency and phlegm turbidity syndrome group was 55.54±13.58 mmol/L(P<0.05),blood sugar was 6.58±0.81 mmol/L(P<0.05),and TG was 2.61±1.5 mmol/L(P<0.05)0.01),HDL-C is 1.62±0.32 mmol/L(P<0.01)higher than that of coronary heart disease with dyslipidemia,spleen deficiency and phlegm turbidity syndrome group.In the control group,ApoB was 0.83±0.21 mmol/L(P<0.05),Apo B/Apo A-I was 0.61±0.18 mmol/L(P<0.01),and Apo A-I was 1.38±0.11 mmol/L(P<0.01)Higher than that of coronary heart disease with abnormal blood lipids,spleen deficiency and phlegm turbidity syndrome group.Apo A-I of coronary heart disease with abnormal blood lipids and spleen deficiency and phlegm turbidity syndrome group is 1.43±0.25 mmol/L(P<0.01),and Apo B is 1.15±0.21 mmol/L(P<0.01)higher than that of coronary heart disease dyslipidemia group with spleen deficiency and phlegm turbidity syndrome.In the control group,PON1 was 664.7±110.17 u/L(P<0.05),and SAA/Apo A-I was 6.77±1.34(P<0.01)lower than that of coronary heart disease with dyslipidemia,spleen deficiency and phlegm turbidity.The S1 P of the control group was 1639.71±172.86 nmol/L(P<0.01),and the ICAM-1 was 304.23±57.51 ng/L(P<0.01),which was lower than the S1 P of the coronary heart disease group with dyslipidemia,spleen deficiency and phlegm turbidity,which was4472.67±498.92 nmol/L,ICAM-1 is 320.34±175.63 ng/L.S1 P of coronary heart disease with abnormal blood lipids and spleen deficiency and phlegm turbidity syndrome group was3821.74±840.48 nmol/L(P<0.01),and ICAM-1 was 866.09±298.06 ng/L(P<0.01)higher than that of coronary heart disease dyslipidemia group with spleen deficiency and phlegm turbidity syndrome S1 P is 4472.67±498.92 nmol/L,ICAM-1 is 320.34±175.63 ng/L.The ET-1 in the spleen deficiency and phlegm turbidity syndrome group of coronary heart disease with dyslipidemia was 72.66±39.98 pg/m L,which was higher than that in the control group,which was 50.61±23.79 pg/m L(P<0.05).The other endothelial factors were not statistically significant.2.The patients with coronary heart disease with dyslipidemia,spleen deficiency and phlegm turbidity were used as state variables,and ROC curves were drawn as S1 P and ICAM-1 test variables.The area under the curve of S1 P and ICAM-1 in the diagnosis of dyslipidemia of coronary heart disease with spleen deficiency and phlegm turbidity are: 0.764,0.999,95%confidence interval is 0.670-0.858,0.997-1.000,P<0.0001,the best cut-off value is 3582.16,384.77,Youden's index is 0.533,0.967,sensitivity is 0.975,1,specificity is 0.558,0.967.The patients with coronary heart disease with abnormal blood lipids and spleen deficiency and phlegm turbidity were used as state variables,and ROC curves were drawn with Apo A-I,Apo B,PON1,SAA/Apo A-I,MPO/PON1,and ET-1 as test variables.Among them,the curve areas of SAA/Apo A-I and ET-1 in the diagnosis of coronary heart disease with dyslipidemia and spleen deficiency and phlegm turbidity are 0.824 and 0.691 respectively,and the 95%confidence intervals are 0.695-0.953,0.490-0.891,P<0.01,P=0.064 The best cut-off values were 8.18 and 50.34,the Youden index were 0.542 and 0.388,the sensitivity was 0.633 and0.933,and the specificity was 0.909 and 0.455,respectively.3.The dyHDL components were correlated with endothelial group factors.The analysis showed that SAA/Apo A-I was correlated with ICAM-1(P<0.01,r=0.13),and S1 P was correlated with i NOS(P<0.05,r=1.53),which was positive.ratio.ICAM-1 and S1P(P<0.01,r=1.44),Apo A-I(P<0.01,r=2.82),HDL-C(P<0.01,r=0.14),S1 P and ET-1(P<0.05),R=0.15),i NOS(P<0.05,r=1.53),e NOS and HDL-C(P<0.05,r=0.41)are correlated in inverse proportion,and the others are not statistically significant.Conclusion:1.Coronary heart disease dyslipidemia is closely related to ICAM-1 in serum S1 P and ICAM-1 in the syndrome of spleen deficiency and phlegm turbidity,which can provide a certain reference for the diagnosis of coronary heart disease dyslipidemia of spleen deficiency and phlegm turbidity.2.SAA/Apo A-I is directly proportional to ICAM-1,S1 P and i NOS.ICAM-1 is correlated with S1 P,Apo A-I,HDL-C,S1 P is correlated with ET-1,i NOS,and e NOS is inversely proportional to HDL-C.3.ET-1 has the ability to predict the syndrome of spleen deficiency and phlegm turbidity in coronary heart disease with abnormal blood lipids.In the early stage of atherosclerosis,the release of nitric oxide subtypes is not obvious. |
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