| Objective:To observe the effect of catgut embedding at acupoints method on the hormone level,TCM syndrome score and Hamilton anxiety score of DOR patients with liver and kidney yin deficiency,and to evaluate the clinical efficacy of this method in the treatment of DOR.Methods:In this study,40 DOR patients with liver and kidney yin deficiency were randomly divided into the experimental group(20 cases)and the control group(20 cases).The experimental group was treated with acupoint catgut embedding method once every 14 days,with 28 days as a cycle,while the control group was treated with Fenmotton,with 28 days as a cycle.After continuous treatment for 3 cycles,bFSH,bE2,bLH,bFSH/bLH TCM syndrome score and Hamilton anxiety score in both groups were compared before and after treatment to evaluate its clinical efficacy,providing clinical evidence for acupoint catemetery method in the treatment of liver and kidney Yin deficiency type DOR and promoting its use.Results:In this study,1 case fell off in the experimental group,2 cases fell off in the control group,and 19 cases were actually included in the experimental group and 18 cases in the control group,totaling 37 cases.(1)Comparison of general data:There were no significant differences in age,course of disease,TCM syndrome score,Hamilton anxiety score and hormone level between the two groups before treatment(P>0.05).(2)Comparison of TCM syndrome scores:After treatment,the TCM syndrome scores in the two groups decreased compared with those before treatment,the difference between the two groups before and after treatment was statistically significant(P<0.05 or P<0.01),especially in the experimental group.There was no statistically significant difference between the major symptom scores of TCM(P>0.05),but there were statistically significant differences in TCM syndrome score and TCM syndrome total score between the two groups(P<0.01).The effect of improving menstrual cycle in the control group was better than that in the experimental group,and the difference of menstrual cycle among the groups was statistically significant(P<0.05).The effect of improving menstrual period,menstrual volume,color quality,waist and knee pain and softness,decreased sexual desire,poor sleep and multiple dreams in the test group was better than that in the control group.There were statistically significant differences in waist and knee pain and weakness,dizziness and tinnitus,hot flushes and sweating,irritability and irritability,dry mouth and tongue pulse among the groups(P<0.05 or P<0.01),while there were no statistically significant differences among the groups with other TCM syndromes(P>0.05).(3)Comparison of Hamilton Anxiety Scale scores:the total score of Hamilton Anxiety Scale decreased in both groups after treatment,especially in the experimental group,and the difference of Hamilton Anxiety Scale total score between groups was statistically significant(P<0.01).There was no significant difference in sensory symptoms,genitourinary symptoms and behavioral performance during the interview(P>0.05),there were statistically significant differences between the remaining HAMA single integral groups(P<0.05 or P<0.01)..(4)Comparison of sex hormone levels:bFSH,bE2,bLH and bFSH/bLH levels in the two groups improvement after treatment compared with before treatment.There was statistically significant difference between bFSH and bFSH/bLH before and after treatment(P<0.05),but there was no statistically significant difference between the two groups(P>0.05),and there was no statistically significant difference between bLH and bE2 before and after treatment(P>0.05).(5)Comparison of the effective rate of TCM syndrome:The total effective rate of the experimental group was 94.74%,among which 0 cases were cured,4 cases were significantly effective and 14 cases were effective.The total effective rate of the control group was 55.55%,including 0 cases cured,0 cases showed obvious effect and 10 cases were effective,and the difference between the groups was statistically significant(P<0.01).(6)Safety evaluation:During the whole course of treatment,1 case of mild nausea was found in the control group,while no obvious adverse reactions were found in the rest.Conclusion:Acupoint catgut embedding therapy has definite clinical effect on DOR with stagnation of liver and deficiency of kidney.Compared with the control group in improving the scores of TCM syndrome and Hamilton anxiety scale,the effect of reducing serum bFSH and bFSH/bLH levels was similar to that of the control group. |
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