Clinical Study Of Blood Residual Egg Yolk Oil Retention Enema In The Treatment Of Chronic Radiation Enteritis

Objective:A prospective randomized controlled trial was aimed to study the clinical efficacy of Xueyu Danhuang butter retention enema in the treatment of chronic radiation enteritis in order to provide evidence-based medical evidence for the clinical value.Methods:The author reviewed the treatment in chronic radiation enteritis of traditional Chinese and western medicine and the historical evolution and research progress of Xueyu Danhuang butter.A total of 72 patients with chronic radioactive enteritis admitted to Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University from March 1,2019 to December 31,2020 were screened.60 patients with chronic radioactive enteritis who met the standards of discharge were finally included.The treatment group and the control group were divided into two groups with 30 cases in each group.In the treatment group,60ml of the Xueyu Danhuang butter was prepared into enema,and in the control group,3g of montmorillonite powder,5mg of dexamethasone and normal saline were prepared into 60ml of enema.The treatment course was 14 days,once a day.Main observation indexes was the degree of radiation response.The minor observation indexes were colonoscopy mucosal change score,traditional Chinese medicine symptoms score,nutrition condition assessment,safety index including routine blood,liver and kidney function,blood coagulation,urine and stool routine and electrocardiogram.Also,we explore the inflammatory indicators and oxidative damage index.Patients were followed up at baseline,7,14,28,56 and 84 days after the treatment.We recorded the relevant symptoms,examinations and scoring results on the record.We compared the relevant indicators within and between the groups.Results:The degree of radioactivity in both groups decreased,the degree of radioactivity in the treatment group could be reduced to a certain extent(P=0.003<0.05),but there may be no significant difference compared with the control group(P=0.057>0.05).In the treatment group,17 cases reached remission,with a rate of 56.67%.In the control group,5 cases reached remission,with a rate of 17.86%.The remission rate in the treatment group was higher than that in the control group and there was a statistical difference between the two groups(P=0.002<0.05).There was no recurrence in the two groups on the 7th,14th,28th and 56th day.On the 84th day,1 patient in the treatment group and 6 patients in the control group had recurrent symptoms,with recurrence rates of 3.33%and 21.4%.The recurrence rate of the treatment group was lower than that of the control group and there was a statistical difference(P=0.048<0.05).The treatment group was better at decreasing VRS scores(P=0.013<0.05),but there was no statistical difference compared with the control group(P=0.968>0.05).The symptoms scores were compared at the baseline and the 7th,14th,28th,56th and 84th days after treatment,and there was a statistical difference in the symptoms scores between different treatment time(P=0.000<0.05),and there was a significant difference between the two groups(P=0.020<0.05).Compared with the control group,the symptoms of abdominal pain,mucinous blood stools and fatigue show statistical differences(P<0.05),but there was no significant difference in the improvement of abdominal pain,diarrhea and reduction of dietary intake compared with the control group(P>0.05).The PG-SGA scores were on the rise,there were few differences in improving the nutritional status(P=0.362>0.05).CRP value was decreased but it made no sense(P=0.937>0.05).SOD levels in both groups were decreased and the treatment group may have an advantage in reducing SOD levels(P=0.047<0.05).The level of LDH in the two groups were basically same(P=0.072>0.05).The two groups of treatment had no significant effect on safety indexes.Conclusion:The treatment of chronic radiation enteritis with Xueyu Danhuang butter has a certain clinical effect,which can reduce the severity of radiation damage,improve the remission rate of radiation response,reduce the disease recurrence.Xueyu Danhuang butter can improve the symptoms of traditional Chinese medicine to a certain extent,showing certain advantages in the symptoms of diarrhea,mucous blood stools and fatigue.However,the data do not support that Xueyu Danhuang butter is superior to the western medicine group in improving the degree of mucosal lesions.