Clinical Research On The Characteristics Of Migraine Syndrome Based On Meridian Differentiation And Nasal Therapy Intervention

Background:Meridian syndrome differentiation is often used to guide the acupuncture treatment of migraine,and its application is relatively limited.Based on the relationship between the meridian circulation and the location of the headache and the visceral collaterals,expanding the application of the meridian syndrome in the clinical diagnosis and treatment of migraine has important practical value.Objective:1.Discuss the distribution characteristics of migraine syndrome based on meridian differentiation,and combine meridian differentiation with viscera differentiation to provide a basis for clinical syndrome differentiation and treatment.2.Observe the clinical efficacy of nasal therapy knot Yinjing medicine in the treatment of acute migraine attacks.Methods:1.Adopting a retrospective research design to collect general data and four-diagnosis information of patients who were diagnosed with migraine in the encephalopathy department and ward of Dongzhimen Hospital of Beijing University of Chinese Medicine from July 2015 to January 2021.According to the theory of meridian differentiation,the collected case data are classified into Shaoyang,Yangming,Taiyang,and Jueyin headaches.The corresponding databases are established,and the clinical symptoms and signs of traditional Chinese medicine are entered.The frequency analysis method in SPSS 25.0 is used to extract the top 20 symptoms of headaches in each meridian and tongue signs with a frequency of ?10%,the association rule algorithm in SPSS Modeler 18.0 is used to analyze the TCM symptom patterns of headaches in each meridian,and the distribution characteristics of syndromes in each meridian are summarized according to the theory of Chinese medicine.2.A randomized controlled trial study was adopted,and finally 30 cases were included in the experimental group and 27 cases in the control group.The experimental group was treated with nasal therapy combined with meridian drugs,and the control group was taken orally with ibuprofen sustained-release capsules.Both groups were observed once at the onset of headache.Record the ratio of the number of people with headache disappeared 2h after medication,the ratio of people with more than 50%headache relief 2h after medication,the ratio of people using analgesics,the time of headache attack and the 0.5h,2h,24h visual analogue scale(VAS)and accompanying symptom score,24h recurrence rate and other indicators,to observe the effectiveness of nasal therapy in the treatment of acute migraine attacks.Use SPSS 25.0 software for statistical analysis.P<0.05 is considered statistically significant,and P<0.01 is considered statistically significant.Results:1.There is no significant difference in the age and gender distribution of the patients with headache.The course of the disease is significantly different through statistical analysis(P<0.05).The course of Jueyin headache is the longest,followed by Shaoyang headache,followed by Taiyang,and Yangming headache.The shortest.The distribution characteristics of TCM syndromes of various classics are summarized as follows:Shaoyang headache:liver-fire headache(swelling and pain on the side of the head,every emotional attack,dizziness,dry mouth,bitter mouth,flank pain,irritability,difficulty falling asleep,tinnitus,dreaminess,sweating,constipation,Red tongue and yellow coating);Yangming headache:phlegm and fire headache(forehead pain,eye pain,dizziness,dry mouth,bitter mouth,sweating,constipation,difficulty falling asleep,dreaming,emotional agitation,red tongue,yellow greasy coating);Taiyang headache:Hanning headache(thumping pain or tight pain in the back of the occiput,every time the feeling of wind and cold is aggravated,the neck is stiff,chills,and the tongue is purple and dark,and the coating is thin and white);Jueyin headache:headache with kidney deficiency(long-term headache,tight head pain,chills,soreness in the waist and knees,frequent nocturia,tinnitus,shallow sleep and easy awakening,red tongue and thin white coating).2.There was no significant difference in age,gender and course of disease between the two groups of patients(P>0.05).There was no significant difference in VAS score,headache degree and accompanying symptom scores before medication(P>0.05),which was balanced and comparable.Comparison of main efficacy indicators:33%of the number of people who completely disappeared after 2 hours of treatment in the experimental group,30%of the people who completely disappeared from headache in the control group,the experimental group was slightly better than the control group,the difference was not statistically significant(P>0.05).Comparison of secondary efficacy indicators:?The proportion of people in the test group with headache relief of more than 50%after 2 hours of medication was 70%;the proportion of people in the control group with headache relief of more than 50%after 2 hours of medication was 78%,the control group was better than the test group,the difference was not statistically significant(P>0.05).?The proportion of people who used other types of analgesics in the experimental group was 7%;the proportion of people who used other types of analgesics in the control group was 4%.The control group was slightly better than the test group,the difference was not statistically significant(P>0.05).?The onset time of the experimental group was 25.08±15.032 minutes,and the onset time of the control group was 28.26±14.894 minutes.The experimental group was slightly better than the control group,and the difference was not statistically significant(P>0.05).?The symptom scores of the two groups after 2 hours of treatment were significantly improved compared with those before treatment(P<0.01),and there was no statistically significant difference in the scores of symptom scores between the two groups after two hours of treatment(P>0.05).?The 0.5h,2h,24h VAS scores of the two groups were significantly improved compared to before treatment(P<0.01)).The difference between the two groups' 0.5h,2h VAS scores was not statistically significant(P>0.05).?The 24h recurrence rate of the test group was 30%,and the 24h recurrence rate of the control group was 20%.The control group was slightly better than the test group,and the difference was not statistically significant(P>0.05).The VAS scores of the two groups of patients at the time of headache recurrence were lower than the VAS scores at the first attack.Conclusions:1.The distribution characteristics of migraine syndrome based on the theory of meridian syndrome differentiation:the disease location is mainly liver,spleen,and kidney,and the pathological nature is mainly cold,phlegm,fire,and deficiency.2.The therapeutic effect of nasal therapy on acute migraine attacks based on syndrome differentiation is equivalent to that of oral ibuprofen sustained-release capsules.The combination of nasal therapy and meridian-inducing drugs can effectively reduce headaches and improve accompanying symptoms.It can be used as an effective treatment for acute migraine.method.