| Object:This subject has found through previous related research that Qiangyue Cream has a good therapeutic effect on localized neurodermatitis.However,the current clinical research on the treatment of localized neurodermatitis with this drug mostly stays at the level of observation of clinical symptoms,and there is no research on the repair of the skin barrier of neurodermatitis by this drug.Therefore,this study took patients with localized neurodermatitis as the research object,and used the commonly used hormone drug in clinical dermatology to treat this disease as the positive control drug.The pseudo-lesion symptom score and TCM syndrome score quantify the different treatment stages of the skin lesions of the subjects,and use the scores to calculate the effective rate and the skin barrier observation index as clinical observation data,not only to evaluate the improvement of clinical symptoms The effectiveness of Yue Cream in the treatment of localized neurodermatitis,and through the analysis of skin barrier indicators,the direct relationship between its curative effect and barrier repair is discussed.It provides data support and clinical basis for the clinical topical treatment of localized neurodermatitis with a simpler and more efficient,low recurrence rate,low side effects,and good compliance.Method:This trial is a non-inferiority randomized positive parallel controlled clinical trial.Collected patients with localized neurodermatitis in our department who met the criteria for inclusion and discharge,and randomly divided them into a test group and a control group with 35 cases each.The test group was treated with Chinese medicine preparation Qiangyue cream externally,and the control group was treated with Youzhuoer ointment externally.Subjects were instructed to follow a uniform and standardized application method,and take the medicine once a day in the morning and evening.The treatment course of the test group was 28 days.In the control group,the course of treatment was 14 days according to the medication instructions.Observation and recording were performed at three time nodes before treatment,14±3 days of treatment,and 28±3 days of treatment,and data analysis was performed through statistical software.During the research process,the adverse reactions of the subjects were recorded and dealt with in time,and finally All selected patients were followed up for observation to assess the recurrence.Result:1 Comparison of the effective rate of the two groups of patients:after 2 weeks of treatment,the total effective rate of the test group was 76.47%,and the total effective rate of the control group was 88.24%.After 4 weeks of treatment,the total effective rate of the two groups was 88.24%,the effective rate of the test group was 79.41%,and the effective rate of the control group was 70.59%.The difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 2.96%,and the control group has not reported any adverse reactions.The recurrence rate of the test group was 17.65%,and the recurrence rate of the control group was 26.37%.The recurrence rate of patients in the experimental group was lower than that in the control group.There was no significant difference after inspection(P>0.05),and it was not statistically significant.2 Comparison of the mean value of clinical symptom index scores of the two groups of patients:the mean total score of clinical symptoms of the two groups of patients before treatment was 22.79±0.30 in the test group and 22.44±0.23 in the control group.There was no significant difference in the mean scores between the two groups(P>0.05).After treatment,the mean total score of clinical symptoms of the two groups of patients was 9.53±0.35 for the test group and 10.65±0.33 for the control group.The difference in the mean scores between the two groups was not statistically significant(P>0.05)3 Comparison of subjective and objective clinical symptom observation indicators between the two groups of patients after treatment:the skin lesion area,color,degree of hypertrophy,number of lichenoid changes,and TCM syndrome scores of the two groups of patients decreased after treatment.Except for subjective symptoms(including itching and insomnia and anxiety symptoms),the average scores of the test group were lower than those of the control group,and the difference was not statistically significant(P>0.05)4 Comparison of skin barrier index evaluation of the two groups of patients:Before treatment,the mean values of the stratum corneum water content(SCH),transdermal water loss(TEWL),water content(ML),and skin barrier scores of the target skin lesions in the test group were respectively:12.33±6.15,10.29±0.89,55.29±2.50,70.15±1.18;the cuticle water content(SCH),transdermal water loss(TEWL),moisture content(ML),skin barrier score of the target skin lesions in the control group The mean values are:10.06±2.24,11.44±1.14,60.3 8±2.11,69.94±1.22.The difference was not statistically significant(P>0.05).The skin barrier values of the target skin lesions of the two groups of patients were different from their own normal skin skin barrier values.After treatment,the mean values of stratum corneum water content(SCH),transdermal water loss(TEWL),water content(ML),and skin barrier scores of the target skin lesions in the test group were:23.41±13.68,2.97±0.33,62.00±,respectively 2.13,80.88±0.91;the mean values of stratum corneum water content(SCH),transdermal water loss(TEWL),moisture content(ML),and skin barrier scores of the target skin lesions in the control group were 14.79±1.99,8.35±0.90,respectively 60.29±1.88,72.47±0.93.Except for the water content score,there is no significant difference(P>0.05).The other scores have statistically significant differences between the two groups after treatment(P<0.05).The test group scores are better than the control group.5 Comparison of skin barrier repair between the two groups of patients with different outcomes:After treatment,the test group and the control group were compared with the value of transcutaneous water loss in the markedly effective group.The difference was significant(P<0.05),and the other measurement indicators were not different.It is statistically significant(P>0.05).The difference in transcutaneous water loss and skin barrier scores between the improved group and the ineffective group was significant(P<0.05),and the difference in other measurement indexes was not statistically significant(P>0.05).The stratum corneum water content(SCH),transdermal water loss(TEWL),skin moisture level(ML),and skin barrier scores of the clinically effective group were significantly different from those of the improved group and the ineffective group,and the three groups The numerical scores of the ineffective group were lowered successively,and the skin barrier score of the ineffective group was the lowest,and the test group's drug repaired the skin barrier better than the control group's drugs.Conclusion:1 Qiangyue Cream has a definite effect in treating neurodermatitis,which can effectively improve the shape,area,color,degree of hypertrophy and the number of lichenoid changes in patients with neurodermatitis.The effect of improving the pruritus symptoms of the disease is not obvious.Its mechanism of action may be related to improving the epidermal skin barrier,reducing the loss of transdermal water loss,and promoting epidermal repair.2 The medicine used in the control group of this study is the weak hormone Youzhuoer Ointment,both of which have therapeutic effects on localized neurodermatitis.The efficacy of Qiangyue Cream is not inferior to that of Youzhuer Ointment.3 In terms of skin barrier repair,Qiangyue cream is better than Youzhal ointment,and its efficacy is positively correlated with the degree of skin barrier repair,which proves that Qiangyue cream has more advantages in improving skin lesion symptoms.4 Qiangyue Cream has a slow and continuous effect in the treatment of localized neurodermatitis.The patient has high compliance,fewer adverse reactions,and low recurrence rate.It can exert a better effect if you insist on using it. |
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