Analysis Of Related Factors Of Recurrence Of Henoch-Schonlein Purpura In Children

Objective: To study the relevant influencing factors of the recurrence of children with Henoch-Schonlein purpura,and to find methods to reduce the recurrence rate of Henoch-Schonlein purpura,so as to provide a strong reference basis for clinical diagnosis and treatment.Methods: Children with Henoch-Schonlein purpura hospitalized in pediatrics of the first hospital of Lanzhou University from January 2019 to April 2021 were selected as the research object.Through the collection of clinical data and follow-up data,they were divided into HSP no recurrence group（139 cases）and HSP recurrence group（72 cases）according to the presence or absence of recurrence.After sorting out the data,the classified variables were tested by chi square test.If the numerical variables meet the homogeneity of variance,independent sample t-test was used,If the variance is uneven,the nonparametric rank sum test is used for univariate analysis,and then logistic regression analysis is used for statistically significant variables,so as to find out the risk factors of Henoch-Schonlein purpura recurrence in children,and evaluate the impact of treatment methods on recurrence.Results:1.There were significant differences between HSP non recurrence group and HSP recurrence group in rash remission time,hospital stay,hormone use during hospitalization,oral hormone after discharge,oral immunomodulator（pidotimod/spleen aminopeptide）after discharge,diet control and exercise restriction after discharge（P < 0.05）.2.There were significant differences in peripheral blood platelet count,lactate dehydrogenase,hemoglobin,triglyceride,total Ig E and urine occult blood between the two groups（P< 0.05）.3.Decreased platelet count,oral hormone after discharge,no oral immunomodulator（pidotimod / spleen aminopeptide）and no exercise restriction after discharge were independent risk factors for HSP recurrence,and the difference was statistically significant（P < 0.05）.Conclusion:1.The first onset of children with Henoch-Schonlein purpura has decreased platelet count,no oral immunomodulator（pidotimod /splenosin）and no exercise restriction after discharge,suggesting a risk of recurrence.2.There is no correlation between hemoperfusion therapy and the recurrence of Henoch-Schonlein purpura.After discharge,oral corticosteroids are risk factors for the recurrence of Henoch-Schonlein purpura,and should be discontinued in time after symptoms are relieved.