Effect Of Preoperative Blood Lipid Level On Clinicopathological Features And Prognosis Of Breast Cancer Patients

Objective: To explore the relationship between preoperative blood lipid level and clinicopathological features and prognosis of breast cancer patients,and to evaluate whether preoperative blood lipid level can be used as a predictor of long-term prognosis of breast cancer patients.Methods: The levels of fasting serum total cholesterol（TC）,triglycerides（TG）,high density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）in the morning and clinical pathological data of 341 breast cancer patients confirmed by pathology were collected retrospectively.Qualitative data using ?2test,rank data were tested by Kruskal-Wallis rank sum test,the Cox proportional risk regression model was used for univariate and multivariate analysis to test independent significant variables,and Kaplan-Meier analysis was used to analyze overall survival（OS）and disease-free survival（DFS）of breast cancer patients.Results:TC level was correlated with tumor stage（P=0.005）and lymph node stage（P=0.004）,TG level was correlated with tumor stage（P<0.001）and tumor molecular typing（P=0.005）.HDL-C levels correlated with tumor stage（P=0.002）,LDL-C levels correlated with tumor stage（P=0.002）and lymph node stage（P<0.001）.Cox proportional hazards regression model showed that low TG,high HDL-C and low LDL-C were beneficial to DFS.Patients with TC levels < 6.2mmol/L VS.patients with TC levels ≥6.2mmol/L,mean OS: 96.2 months VS.95.4 months（P = 0.556）,mean DFS of 95.9 months in patients with TC levels < 6.2mmol/L and mean DFS of 94.0 months in patients with TC levels ≥6.2mmol/L（P=0.122）.Patients with TG levels < 2.3mmol/L VS.patients with TG levels ≥2.3mmol/L,mean OS: 96.7 months VS.94.1 months（P =0.103）,mean DFS 96.4 months in patients with TG levels < 2.3mmol/L and mean DFS92.1 months in patients with TG levels ≥2.3mmol/L（P=0.003）.Patients with HDL-C level < 1.04mmol/L VS.patients with HDL-C level ≥1.04mmol/L,mean OS: 94.7months VS.97.6 months（P = 0.019）,Mean DFS of 93.2 months in patients with HDL-C level < 1.04mmol/L and mean DFS of 97.6 months in patients with HDL-C water ≥1.04mmol/L（P=0.003）.Patients with LDL-C <3.4mmol/L VS.patients with LDL-C ≥3.4mmol/L,mean OS: 96.8 months VS.94.1 months（P=0.026）,mean DFS of 96.5 months in patients with LDL-C < 3.4mmol/L and mean DFS of 92.1 months in patients with LDL-C ≥3.4mmol/L（P=0.002）.Conclusion: Preoperative blood lipid levels have a certain correlation with tumor stage,lymph node stage and molecular typing of breast cancer in patients with breast cancer.Preoperative TG level,HDL-C level and LDL-C level may be relevant predictive factors affecting DFS in breast cancer patients.