Study On The Differential Value Of Fecal Calprotectin Combined With Procalcitonin Between Bacterial And Viral Diarrhea In Children

Objective To investigate the differential value of fecal calprotectin combined with procalcitonin between bacterial and viral diarrhea in children.Method A total of 135 children with acute infectious diarrhea admitted to the hospital from October 2019 to February 2022 were selected,including 65 cases of bacterial infection and 70 cases of viral infection.The differences in the levels of fecal calprotectin and procalcitonin were compared between the two groups,and the identification efficiency was analyzed by the ROC curve.Results 1.The area under the ROC curve,sensitivity and specificity of fecal calprotectin combined with procalcitonin were 0.905,87.69 % and 90.00 %,which were better than those of fecal calprotectin,procalcitonin,C-reactive protein and white blood cell.2.The area under the ROC curve of fecal calprotectin was significantly larger than that of procalcitonin（P<0.05）;the area under the ROC curve of fecal calprotectin combined with procalcitonin was significantly larger than that of fecal calprotectin and procalcitonin（P<0.05）.3.The levels of fecal calprotectin,procalcitonin,C-reactive protein and white blood cell in the bacterial group were significantly higher than those in the virus group（P<0.05）.4.The incidence of bloody and purulent stool in the bacterial group was significantly higher than that in the virus group（P<0.05）;the incidence of myocardial and hepatic damage in the virus group was significantly higher than that in the bacteria group（P<0.05）.Conclusions 1.Fecal calprotectin in the identification of bacterial and viral diarrhea was better than procalcitonin,C-reactive protein and white blood cell;the combined evaluation of fecal calprotectin and procalcitonin was better than single evaluation of fecal calprotectin and procalcitonin.2.Compared to children with viral diarrhea,bacterial diarrhea had higher levels of fecal calprotectin,procalcitonin,C-reactive protein,and white blood cell,and were more prone to have purulent and bloody stool.3.Children with viral diarrhea had higher risk of myocardial and hepatic damage than bacterial diarrhea.