Research On The Medication Rules And Academic Thoughts Of Sichuan Wen’s Department Of Dermatology In The Treatment Of Androgenic Alopecia Based On The TCMISS

Objective:Analysis 300 prescriptions of androgenic alopecia patients diagnosed and treated by doctors from‘Sichuan Wen’s Department of Dermatology ’ through Traditional Chinese Medicine Inheritance Support System V2.50(TCMISS)to summarize the syndrome differentiation rules and prescription characteristics rules of ‘Sichuan Wen’s Department of Dermatology’ in the treatment of androgenic alopecia,make up a new prescription of traditional Chinese medicine,generate new prescriptions and observe the clinical effect.To sort out the medication rules and academic thoughts of Sichuan Wen’s Department of Dermatology in the treatment of androgenic alopecia and provide new ideas and medication references for the clinical treatment.Methods:1.Collect 300 prescriptions of androgenic alopecia patients diagnosed and treated by doctors of Sichuan Wen’s Department of Dermatology from August 2019 to July2020.Patients’ four diagnostic information,treatment methods and prescriptions of traditional Chinese medicine should be classified and recorded,preprocess the data,and input it into the TCMISS.Through the data analysis methods such as rule analysis,complex entropy clustering analysis and unsupervised entropy hierarchical clustering analysis,obtained the syndrome distribution,high-frequency drugs and commonly used drugs,and make up new prescriptions.2.Select a new prescription suitable for androgenic alopecia(damp-turbid syndrome)and add or subtract drugs.A self-control study was conducted to observe the short-term clinical effect of "seborrheic alopecia new prescription" in 36 androgenic alopecia patients with syndrome differentiation of dampness and turbid.All patients signed informed consent and were treated with new prescription suitable for androgenic alopecia(damp-turbid syndrome)during the treatment period.The alopecia and hair growth were compared before treatment,the 1st month,the 2nd month and the 3rd month of treatment of treatment.SPSS23.0 was used to analyze the data and draw a conclusion.Results:1.Through the analysis of 300 prescriptions of androgenic alopecia patients,it is concluded that the experience of Sichuan Wen’s Department of Dermatology in the diagnosis and treatment of androgenic alopecia is as follows:(1)The four syndromes with the highest frequency are damp-turbid syndrome,spleen deficiency and damp accumulation syndrome and damp-heat syndrome anddampness-stasis syndrome.(2)Coix seed,Tangerine peel,Hedyotis diffusa,Atractylodes,Ginger Magnolia,Atractylodes macrocephala and Jianqu are high frequency drug in this research.(3)Through the drug association rules,it is concluded that the common combinations of two kinds of drugs are: ‘Ginger Magnolia with tangerine peel’,‘Hedyotis diffusa with Coix seed’,‘Jianqu with Hedyotis diffusa’,‘Ginger Magnolia with Hedyotis diffusa’,‘Atractylodes macrocephala with Coix seed’,‘Jianqu-Coix seed’,‘Ginger Magnolia with Coix seed’‘Atractylodes lanceolata with Coix seed’,‘Jianqu with Ginger Magnolia’,‘Ginger Magnolia and Atractylodes lancea’;(4)5 potential new prescriptions through entropy hierarchical clustering mining,among which New prescription 3,4 and 5 cover the diagnosis and treatment of dampness,heat,blood stasis,turbid,deficiency and other aspects of the disease,which can be used as a basic prescription for addition and subtraction treatment in clinical treatment.2.The addition and subtraction of the new prescription NO.4 was applied to the short-term clinical observation of androgenic alopecia(damp-turbid syndrome),36 patients were included in the observation,and 34 cases were actually completed.During the treatment period,A gradual downward trend exists in the total symptom score of each treatment period.suggesting that the treatment was effective(P < 0.05).Compared with the individual scores of alopecia symptoms,the symptom scores showed a downward trend,suggesting that the symptoms were significantly improved(P < 0.05).The symptom score of hair growth was compared before and after treatment,which indicated that it showed a downward trend during the treatment(P < 0.002),suggesting that the new alopecia prescription had a certain hair growth effect.After treatment,the total effective rate of 34 patients was 76.47%.Conclusion:1.Analysis and data mining prescriptions of androgenic alopecia patients diagnosed and treated by doctors from‘Sichuan Wen’s Department of Dermatology ’through Traditional Chinese Medicine Inheritance Support System V2.50(TCMISS)to obtain the mainly syndrome types,medication characteristics,common drug combinations and make up new prescriptions of ‘Sichuan Wen’s Department of Dermatology ’ in the treatment of androgenic alopecia.The high frequency symptoms are caused by "dampness" evil.Damp-turbid syndrome,spleen deficiency and dampness accumulation syndrome,dampness-heat syndrome and dampness-stasis syndrome are the main clinical syndromes.Anti-dampness medicine is the most commonly used medicine in the prescription.2.The short-term clinical efficacy of the new prescription suitable for androgenic alopecia(damp-turbid syndrome)was observed,and the short-term effect was positive,but the long-term effect was needed to evaluate the therapeutic effect.3.‘Sichuan Wen’s Department of Dermatology ’ believe that "dampness" evil is the main etiology and pathogenesis of of androgenic alopecia.In terms of treatment,treat from dampness should be emphasized.