Correlation Between PCOS-IR And Lifestyle And Distribution Of TCM Syndrome Types

Objective:To preliminarily explore the positive rate of IR in patients with PCOS and its correlation with life style and heredity,and preliminarily explore the distribution pattern of TCM syndromes in patients with PCOS-IR,so as to provide basis for the prevention and treatment of this disease and TCM clinical syndrome differentiation.Method:In December 2019-January 2021 visits in affiliated hospital of chengdu university of TCM has been diagnosed with PCOS and 210 patients were included in this study criteria,the questionnaire survey to collect the general situation and life style,family history of genetic information,for the IR positive cases further the TCM four diagnostic data collection,establishing database,using R language 3.4.0 data processing,analysis,single factor analysis using chi-square,multi-factor analysis using binary classification Logistic stepwise regression analysis,the TCM syndrome type distribution using frequency analysis.Results:1.Among 210 PCOS patients in this study,123 cases were combined with IR,and the positive rate of IR was 58.57%.2.Univariate analysis results showed that BMI,dietary preference(light,greasy,sweet,spicy),consumption of fruits and vegetables,consumption of sweets,consumption of fast food or takeaway,staying up late,exercise habits,bad mood,family history of diabetes and other factors were related to PCOS-IR(P<0.05).3.Multivariate analysis showed that BMI,sweets,late night,bad mood,family history of diabetes were positively correlated with PCOS-IR,which were all risk factors(OR>1).Fruit and vegetables,exercise were negatively correlated with PCOS-IR(OR<1),which might be protective factors of PCOS-IR.4.Among the 123 PCOS-IR patients in this study,there were 20 TCM syndromes.The top three TCM syndromes were 27 cases of kidney deficiency and liver stagnation with blood stasis(21.95%),18 cases of kidney deficiency and phlegm dampness(14.63%),and 17 cases of kidney deficiency and liver stagnation(13.82%)in turn.In the analysis of single syndrome type,the frequency of kidney deficiency syndrome was the highest(107 cases(86.99%)),followed by liver stagnation syndrome(61cases(49.59%)),blood stasis syndrome(60 cases(48.78%)),phlegm dampness syndrome(54 cases(43.90%)),spleen deficiency syndrome(18 cases(14.63%)),and dampness-heat syndrome(6 cases(4.88%)).Conclusion:1.The insulin resistance rate of PCOS patients reached 58.57%,and more than half of PCOS patients were complicated with IR.Therefore,the prevention and treatment of IR is urgent.2.The main risk factors of body mass index of PCOS-IR,sweets to eat much,often stay up late,bad mood,family history of diabetes,the factors that protect the fruits and vegetables enough,regular exercise,as a result,whether PCOS patients or in PCOS patients,all should strengthen health education,advocate healthy way of life,such as optimizing the structure of diet,strengthening exercise,avoid to stay up late,assure enough sleep,chang emotions.3.In this study,the single syndrome type of PCOS-IR patients was mainly kidney deficiency syndrome,followed by liver depression syndrome,blood stasis syndrome,phlegm dampness syndrome,spleen deficiency syndrome and dampness-heat syndrome.The TCM syndrome type mainly consisted of the complex syndrome formed by the above single syndrome types,mainly including kidney deficiency and liver stagnation combined with blood stasis syndrome,kidney deficiency and phlegm dampness syndrome,kidney deficiency and liver stagnation syndrome and 20 other syndromes,which were mostly mixed with deficiency and excess syndrome.