Analysis Of TCM Symptoms Of Influenza In Children In Shenzhen During Winter And Spring Of 2019-2020

Objective: Influenza(influenza)is an acute respiratory infectious disease caused by human influenza virus,which is seasonal.This article aims to analyze the epidemiology of influenza,the characteristics of TCM syndromes and the situation of application of proprietary Chinese medicines in order to guide the diagnosis and treatment of influenza and strengthen the propaganda and education of standardized use of Chinese patent medicines.Research methods: In this study,a cross-sectional study was conducted to collect influenza cases in Shenzhen children’s Hospital from October 2019 to February-2020.The relevant literature was analyzed,and the TCM syndromes questionnaire for influenza was drawn up by experts,and 1098 patients in accordance with clinical cases were collected.To analyze the epidemiology of influenza,the distribution characteristics of TCM syndrome and the use of Chinese patent medicine.Results:1.From October 2019 to February 2020,the minimum age of confirmed influenza cases was 1 month,the maximum age was 17 years,and the average age was 5.30 ± 3.08 years.The most preschool children were 472(42.99%),followed by school-age 331(30.14%),early childhood 188(17.13%),infancy 73(6.65%)and adolescence(3.09).2.There were 995 cases of wind heat invading Wei syndrome(90.60%),73 cases of heat attacking the lung syndrome(6.70%),10 cases of toxic heat blocking the lung syndrome(0.90%),and 20 cases of toxic heat invagination syndrome(1.8%).There were 4 cases(4/ 1098)without fever in the four syndrome types,and 1094 / 1098 cases were treated with fever,accounting for 99.6%.The syndrome type is mainly moderate and high fever.The time of fever treatment was the most in one day,and the percentages of the four syndrome types were 70.9%,60.3%,80.0% and 70.0% respectively.3.The independent sample rank sum test of WBC(109 / L),NE%,ly%,CRP(mg / L)and four syndrome types in blood routine examination,P < 0.05,it is considered that there is significant difference in the distribution of WBC(109 / L)among the above four syndrome types.WBC(109 / L),NE% and CRP(mg / L)were statistically significant between wind heat invading the lung syndrome and heat toxin invading the lung syndrome(P < 0.0125).WBC(109 / L)7.8(6.3,10.1),NE% 71.6(61.8,78.8)in wind heat invading the lung syndrome were higher than that in heat toxin invading the lung syndrome 7.8(6.3,10.1),65.4(52.5,77.8),and CRP(mg / L)3.3(1.0,7.9)in wind heat invading the lung syndrome was lower than that in heat toxin invading the lung syndrome 5.4(2.7,12.1).Ly% was statistically significant between wind heat invading stomach syndrome and toxic heat invagination,ly% 17.5(12.0,25.4)was less than toxic heat invagination 23.7(18.2,34.3),CRP(mg / L)was statistically significant between heat invading lung syndrome and toxic heat invagination syndrome,P < 0.0125,heat invading lung syndrome 5.4(2.7,12.1)was greater than toxic heat invagination syndrome2.8(0.6,6.0).4.One case of influenza A and B combined infection was wind heat invading health syndrome,1076 cases of influenza A,973 cases(90.43%)of stroke heat invading health syndrome,and 21 cases of influenza B were wind heat invading health syndrome.5.Therapeutic medication: the ratio of useless Chinese patent medicines among the four syndrome types was greater than 50.00%,56.48%,65.75%,60.00% and 60.00%respectively.From high to low,the frequency of drug use in the syndrome of wind heat invading Wei was 154(15.48%)of Xiaoer douqiao Qingre granules,81(8.14%)of Chaihuang granules,42(4.22%)of Pudilan Xiaoyan oral liquid,28(2.82%)of Yinhu Ganmao powder,28(2.82%)of an’erning granules,28(2.82%)of Jinlian Qingre effervescent tablets,17(1.71%)of antiviral oral liquid,16(1.61%)of Lianzhi Xiaoyan dispersible tablets,15(1.11%)of Xiaoer jiebiao oral liquid Xiaoer baotaikang granule 9(0.90%),Lanqin oral liquid 7(0.70%),Lianhua Qingwen capsule 3(0.30%),Qingxuan Zhike granule 2(0.20%),orange phlegm Keye 1(0.10%),Huanglong Zhike granule 1(0.10%),Wufu Huadu tablet 1(0.10%).The frequency of using Chinese patent medicine in the syndrome of heat toxin attacking the lung from high to low is Chaihuang granule 5(6.85%),Jinlian Qingre effervescent tablet 5(6.85%),Xiaoer daiqiao Qingre Granule 4(5.48%),Lanqin oral liquid 3(4.10%),Xiaoer baotaikang granule 3(4.10%),an’erning granule 2(2.73%),Lianzhi Xiaoyan dispersible tablet 1(1.37%),antiviral oral liquid 1(1.37%)and Pudilan Xiaoyan oral liquid 1(1.37%).The frequency of using Chinese patent medicine in the syndrome of toxic heat blocking the lung was Lanqin oral liquid 3(30.00%)and Jinlian Qingre effervescent tablet 1(10.00%).The frequency of using Chinese patent medicine in toxin heat invagination syndrome from high to low was Chaihuang granule 2(10.00%),Xiaoer douqiao Qingre Granule 2(10.00%),Lanqin oral liquid 2(10.00%),Pudilan Xiaoyan oral liquid 1(5.00%)and Jinlian Qingre effervescent tablet 1(5.00%).Conclusion:1.through the study of influenza in Shenzhen during the winter and spring of October2019 in February-2020,it is necessary to remind medical institutions to strengthen influenza vaccine education,especially vaccination for preschool children,so as to reduce the infection rate of influenza virus.2.1098 influenza cases in winter and spring from 2019 to 2020 were mainly of wind heat invading health syndrome.Through the analysis of the distribution position of WBC(109/ L),NE%,ly% and CRP(mg / L)in blood routine among the four syndrome types,it can be seen that there are significant differences in their distribution among the four syndrome types.The rank sum test of two independent samples showed that WBC(109 /L)7.8(6.3,10.1),NE% 71.6(61.8,78.8)of wind heat invading health syndrome were higher than that of heat poisoning invading lung syndrome 7.8(6.3,10.1),65.4(52.5,77.8),and CRP(mg / L)3.3(1.0,7.9)of wind heat invading health syndrome was lower than that of heat poisoning invading lung syndrome 5.4(2.7,12.1).Ly% 17.5(12.0,25.4)of wind heat invading Wei syndrome was less than 23.7(18.2,34.3)of toxic heat invading Wei syndrome,and CRP(mg / L)5.4(2.7,12.1)of toxic heat invading lung syndrome was greater than 2.8(0.6,6.0)of toxic heat invading Wei syndrome.But this conclusion needs more sample size to verify.3.through the analysis of the use of four kinds of TCM patent medicines for influenza,it was learned that the outpatient and emergency doctors in Shenzhen children’s hospital were more standardized in choosing Chinese patent medicines for epidemic influenza and mild heat syndrome,while the selection of Chinese patent medicines for severe fever and mild severe influenza was poor.It can help the children with severe influenza to shorten the course of disease,shorten the length of stay,reduce the cost of treatment and reduce the incidence of adverse reactions.