Professor Yang Gongxu’s Academic Experience And Medication Rule In The Treatment Of Knee Osteoarthritis Based On Syndrome Differentiation Of Six Channels

Objective:This paper aims to make descriptive statistics,correlation analysis and clustering analysis of the collected medical records of Professor Yang Gongxu’s treatment of knee osteoarthritis,and summarize Professor Yang’s academic experience and therapeutic method in treating knee osteoarthritis with the theory of Six-Meridians Syndrome Differentiation,then gives some typical cases.Through the research,we can better inherit and carry forward Professor Yang’s clinical academic experience,and develop ideas for the clinical treatment of knee osteoarthritis.Methods:1.Analyze Professor Yang’s treatment of knee osteoarthritis;delve into typical cases;combine with relevant TCM classics,works and literatures;detailed analysis and summary etiology,pathogenesis,Six-Meridians Syndrome Differentiation Thought and commonly used prescription.2.Normalized processing 69 cases of knee osteoarthritis,to establish the TCM database of Professor Yang’s treatment of knee osteoarthritis.Deeply research the type,frequency,nature,meridian tropism,compatibility law of medications used,using frequency analysis,clustering analysis,correlation analysis and other methods by SPSS statistical software.Summarize Professor Yang’s academic experience in treating knee osteoarthritis.Results:1.There were 14 kinds of TCM involved,of which 5 are commonly used types.Sort by cumulative frequency of use:Buxu medicine（363）,Jiebiao medicine（173）,Huoxuehuayu medicine（108）,Qufengshi medicine（80）,Anshen medicine（70）.2.There are 7 kinds of TCM’s nature involved.Sort by frequency of use:Bitter（455）,hot（425）,sweet（406）,sour（129）,salty（47）,light（35）,astringent（5）.3.There are 5 kinds of TCM’s property involved.Sort by frequency of use:Warm（548）,flat（176）,cold（173）,hot（37）,cool（2）.4.There are 5 kinds of TCM’s meridians tropism involved.Sort by frequency of use:kidney（495）,spleen（469）,lung（416）,heart（372）,liver（360）.5.In association analysis,when the preceding paragraph is set to 1,the combinations with high confidence are as follows:Paeoniae Radix Alba-Zingiberis Rhizoma Recens,Cinnamomi Ramulus-Zingiberis Rhizoma Recens,Paeoniae Radix Alba-Jujubae Fructus,Cinnamomi Ramulus-Jujubae Fructus,Psoraleae Fructus-Drynariae Rhizoma,Cinnamomi Ramulus-Glycyrrhizae Radix Et Rhizoma,Cinnamomi Ramulus-Pol Ygalae Radix,Cinnamomi Ramulus-Paeoniae Radix Alba.6.When the result of cluster analys is at 20.0 on the distance scale,32 TCM can be divided into 9 categories:（1）Bupleuri Radix,Scutellariae Radix,Ginseng Radix Et Rhizoma;（2）Siegesbeckiae Herba,Notopterygii Rhizoma Et Radix,Sinomenii Caulis,Trachelospermi Caulis Et Folium,Gano Derma,Schizonepetae Herba;（3）Atractylodis Macrocephalae Rhizoma,Saposhnikoviae Radix;（4）Angelicae Pubescentis Radix,Dipsaci Radix;（5）Achyranthis Bidentatae Radix,Dendrobii Caulis;（6）Phellodendri Chinensis Cortex,Amomi Fructus,Zingiberis Rhizoma,Asari Radix Et Rhizoma,Aconiti Lateralis Radix Praep Arata,Poria;（7）Psoraleae Fructus,Drynariae Rhizoma,Pol Ygalae Radix,Astragali Radix,Cervicornu;（8）Jujubae Fructus,Zingiberis Rhizoma Recens,Cinnamomi Ramulus,Paeoniae Radix Alba,Glycyrrhizae Radix Et Rhizoma;（9）Ostreae Concha.Research Conclusions:1.Cartilage has properties of Jin,Gu and Rou,and meridian tropism in liver,spleen and kidney.The internal cause of knee osteoarthritis is liver,spleen and kidney.2.Every pain has its exterior syndrome.External causes of knee osteoarthritis are attributed to wind-cold/heat and pathogenic dampness attacking superficies.3.Knee osteoarthritis is syndrome of deficiency Ben and excessive Biao,mainly deficiency Ben.The main treatment options are Strengthening vital qi and eliminating pathogens.The former helps tonifying the liver,spleen and kidney;and the latter helps dispelling cold,relieving exterior,dispelling dampness and draining collateral.4.Knee osteoarthritis is mainly composed of Shaoyin and can have other pathological changes.Common combinations are Shaoyin-Shaoyang,Shaoyin-Jueyin,Shaoyin-Taiyang,ShaoyinYangming.The methods of frequent drug use for all kinds of situation were summarized.