Study On The Relationship Between Risk Factors For Children With Mycoplasma Pneumoniae Pneumonia And Distribution Characteristics About Syndrome Types Of Traditional Chinese Medicine

ObjectiveThe objective was to use retropective analysis of risk factors affecting the severity of Mycoplasma pneumoniae pneumonia(MPP)in children and distribution characteristics about syndrome types of traditional Chinese Medicine.Exploration of the correlations between risk factors affecting the severity and syndrome types of traditional Chinese Medicine.MethodsCollecting the hospitalized children with MPP in pediatric wards from the First Affiated Hospital of Guangzhou University of Chinese Medicine from January 2019 to December 2019.Including basic hospitalized children information,laboratory test items,syndrome types of traditional Chinese Medicine and state of illness.The children were divided into severe group and mild group according to disease severity,whether the child met the diagnostic criteria of refractory Mycoplasma penumoniae pneumonia(RMPP)or severe Mycoplasma pneumonia(RMPP).Statistical analysis was performed using SPSS26.0 statistiacl software.Results1.A total of 889 cases were collected in this study.There were 626 cases(70.4%)in mild group,and 263 cases(29.6%)in severe group.There were 467 cases of males and 422 cases of females;the age range was 3 months old to 14 years old.324 were male and 302 were female in mild group;the age range was 3 months old to 14 years old.143 were male and 120 were female in severe group;the age range was 4 months old to 13 years old.The differences between gender,age and weight in mild group and severe group were not statistically significant(P>0.05).2.The law of MPP was phlegm heat obstructing Lung syndrome,cold-heat complicating syndrome,wind-heat blocking lung type,wind-cold closing lung type,toxin-heat blocking lung syndrome.3.In the feild of onset season,there was significant difference in seasonal distribution between the two groups.The hospitalized children of mild group distributed mainly spring(20.3%),summer(42.8%)and autumn(24.6%),while the severe group distributed mainly summer(33.8%),autumn(27.8%)and winter(28.1%).In severe group,wind-heat blocking lung type group distributed mainly winter(52.0%),phlegm heat obstructing Lung syndrome group distributed mainly summer(42.0%),and cold-heat complicating syndrome group distributed mainly autumn and winter(both 33.9%).4.In risk factors analysis: Compared with Platelet Donors(PLT)>450×10^9/L,PLT≤450×10^9/L of the child might have lower risk of MPP exacerbation(P=0.042<0.05,OR=0.600<1).Compared with lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia in imaging performances,the child with small patchy infiltrates shadow might have lower risk of MPP exacerbation(P<0.001,OR=0.575<1).Compared with the onset season in winter,other seasons might have lower risk of leading to the aggravation of MPP(P<0.05,OR<1).Other syndrome types of traditional Chinese Medicine were no differences in the risk of MPP exacerbationo compared with cold-heat complicating syndrome(P>0.05).5.In wind-heat blocking lung type: Compared with winter,summer might have lower risk of leading to the aggravation of MPP(P=0.006<0.05,OR=0.154<1).6.In phlegm heat obstructing Lung syndrome: Compared with age ≤ 3 years old,the child with age > 3 years old might have lower risk of MPP exacerbation(P=0.026<0.05,OR=0.632<1).Compared with PLT > 450×10^9/L,PLT ≤ 450×10^9/L of the child might have lower risk of MPP exacerbation(P=0.009<0.05,OR=0.443<1).The laboratory test item of hypersensitive C-reactive protein(hs-CRP)was risk factor for phlegm heat obstructing Lung syndrome(P<0.001,OR=1.014>1).Compared with lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia in imaging performances,the child with small patchy infiltrates shadow might have lower risk of MPP exacerbation(P=0.004<0.05,OR=0.578<1).Compared with the winter,spring and autumn might have lower risk of leading to the aggravation of MPP(P<0.05,OR<1).7.In cold-heat complicating syndrome: Compared with lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia in imaging performances,the child with small patchy infiltrates shadow might have lower risk of MPP exacerbation(P=0.005<0.05,OR=0.590<1).Compared with winter,other seasons might have lower risk of leading to the aggravation of MPP(P<0.05,OR<1).ConclusionIt was known from the study that the law was phlegm heat obstructing Lung syndrome,cold-heat complicating syndrome,wind-heat blocking lung type,wind-cold closing lung type,toxin-heat blocking lung syndrome in the field of syndrome types of traditional Chinese Medicine.It has been found that winter,PLT > 450×10^9/L and imaging performances which are lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia might be the risk factors for MPP exacerbation.In wind-heat blocking lung type:Compared with winter,summer might have lower risk of leading to the aggravation of MPP.In phlegm heat obstructing Lung syndrome: Age > 3 years old,winter,PLT >450×10^9/L and imaging performances which are lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia were the risk factors for MPP exacerbation.In cold-heat complicating syndrome: winter and imaging performances which are lobar pneumonia,pleural effusion,atelectasis,segmental pneumonia were the risk factors for MPP exacerbation.