Clinical Observation Of Fire Acupuncture In Treating Chemotherapy-induced Oral Mucositis Of Breast Cancer

ObjectiveThis study observed the clinical efficacy of fire needle in the treatment of chemotherapy-induced oral mucositis of breast cancer,and explored whether the fire needle could improve the pain score,main symptoms and signs score,average ulcer stage,etc.,so as to clarify the clinical value of fire needle in the treatment of chemotherapy-induced oral mucositis of breast cancer.MethodIn this study,60 patients were randomly divided into experimental group and control group,30 cases in each group.The experimental group was treated with fire needle: according to the size of the ulcer surface,select the appropriate times to prick the ulcer surface,once every other day,for 7days.The control group was treated with Kangfuxin solution: after getting up in the morning,after lunch and before going to bed at night,10-15 ml Kangfuxin solution was rinsed once for 7 days.The pain score,main symptoms and signs(area,number,exudation,hyperemia,edema,pain,burning sensation,total score)of chemotherapy-induced oral mucositis were evaluated before treatment and on the 3rd,5th,7th and 9th day of treatment.Main outcome measures: average ulcer stage,pain score,secondary outcome measures,main symptoms and signs evaluation,safety evaluation.The data were analyzed by SPSS software.Results1.Baseline comparison of general data between the two groups before treatment was conducted,There were no statistically significant differences in age,onset time,treatment time,WBC count,neutrophil count,chemotherapy regimen,hormone use,long-term white rising needle use,TCM syndrome type,oral mucosa classification before treatment,pain score,main symptoms and signs scores between the two groups were not statistically significant(P >0.05).The baseline data of the two groups were balanced and had good comparability.2.Before and after treatment,the pain score of the experimental group was 1.90 ± 0.71 on the third day of treatment,0.27 ± 0.52 on the fifth day of treatment,and 0 ± 0 on the seventh and ninth day of treatment.Compared with before treatment,the pain scores of the experimental group were decreased(P < 0.05).On the 3rd day of treatment,the scores of area,exudation,hyperemia,edema,pain,burning sensation and total score decreased compared with those before treatment(P < 0.05);on the 5th,7th and 9th day of treatment,the area,number,exudation,hyperemia,edema,pain,burning sensation and total score decreased compared with those before treatment(P < 0.05).3.The control group before and after treatment: the pain score of the third day of treatment was 1.87 ± 0.68;the fifth day of treatment was 1.23± 0.68;the seventh day of treatment was 0.13 ± 0.35;the ninth day of treatment was 0 ± 0;compared with before treatment,the pain score was decreased(P < 0.05).On the 3rd day of treatment,the scores of area,exudation,hyperemia,edema,pain,burning sensation and total score decreased compared with those before treatment(P < 0.05);on the 5th,7th and 9th day of treatment,the area,number,exudation,hyperemia,edema,pain,burning sensation and total score decreased compared with those before treatment(P < 0.05)4.Comparison of indicators between groups: there was no significant difference in pain score on the third day of treatment(P > 0.05);the pain score of the experimental group was lower than that of the control group on the 5th and 7th day of treatment(P < 0.05);the pain score of both groups was 0 on the 9th day of treatment(P > 0.05).Compared with the control group,the ulcer area,exudation,congestion,edema,burning sensation and total score of the experimental group on the third day of treatment were lower than those of the control group(P < 0.05);on the fifth day of treatment,the ulcer area,number of ulcers,exudation,congestion,swelling,ulcer pain,burning sensation and total score of the experimental group were lower than those of the control group(P < 0.05);On the 7th day of treatment,the ulcer area,number,pain and total score of the experimental group were lower than those of the control group(P < 0.05);on the 9th day of treatment,the scores of 8 items in both groups were 0(P > 0.05).The overall average ulcer period was 5.97± 0.83 days in the experimental group and 6.76 ± 1.01 days in the control group(P < 0.05).During the treatment,there was no difference in the number of WBC and neutrophil between groups after treatment(P > 0.05).There was no difference in pain score between the groups on the 3rd,7th and 9th day of treatment(P > 0.05),but there was difference between the groups on the 5th day(P < 0.05);there was no difference in the pain score between the groups on the 3rd,5th,7th and 9th days of treatment(P > 0.05).There was no significant difference between the two groups in the average ulcer period(P >0.05).The average ulcer period of the experimental group was shorter than that of the control group(P < 0.05),and there was no significant difference between the two groups(P > 0.05).5.Safety: no adverse events occurred in both groups.ConclusionFire needle can effectively and safely improve the pain score and main symptoms and signs scores of chemotherapy-induced oral mucositis of breast cancer,and it has faster effect and shorter recovery time than Kangfuxin Liquid gargle,without obvious adverse reactions.