Meta-analysis Of The Effect Of Platelet-rich Fibrin In Alveolar Ridge Preservation

Objective: Platelet-rich fibrin(PRF)is widely used in the field of oral implantology,but the clinical effectiveness of using PRF for alveolar ridge preservation after tooth extraction remains controversial.The purpose of this study was to systematically evaluate the effectiveness of using PRF in alveolar ridge preservation after tooth extraction.Methods: Randomized controlled trials(RCTs)published before August25,2020 about the use of PRF after tooth extraction were searched through the Pub Med、Embase、Cochrane Library、How Net、Wanfang、CBM databases and clinical trial registration centers in China and the United States.Outcome indicators included in the studies included dry socket occurrence,alveolar bone resorption in the horizontal and vertical directions,and the percentage of new bone.Meta-analysis was conducted with Review Manager Version 5.4software.Results: A total of 706 studies were retrieved.After screening,8 studies were analyzed quantitatively.Meta-analysis results showed that PRF could reduce the absorption of alveolar bone after tooth extraction,which reduced the horizontal bone mass(WMD=-0.71,95% CI=-1.11 to-0.32,P<0.05)and buccal(WMD=-1.38,95% CI=-1.87 to-0.88,P<0.05)and lingual sides(WMD=-0.49,95% CI=-0.92 to-0.06,P<0.05)and increased the percentage of new bone(SMD=1.24,95% CI =0.25 to 2.23,P<0.05).However,there was no significant difference in preventing the occurrence of dry socket(RD <0.01,95% CI=-0.05 to 0.04,P=0.95)and reducing bone absorption in the vertical direction of mesial(WMD=-0.11,95% CI=-1.17 to 0.95,P=0.84)and distal(WMD=-0.66,95% CI=-1.93 to 0.60,P=0.30)alveolar ridge after tooth extraction.Conclusions:1.The use of PRF after tooth extraction effectively preserves the bone volume in the horizontal direction of the alveolar ridge and accelerates the growth of new bone2.The use of PRF after tooth extraction has no significant effect on reducing the incidence of alveolar osteitis after surgery.3.The use of PRF after tooth extraction was effective in reducing postoperative buccolingual vertical bone resorption,but there was no significant difference in the mesial and distal vertical directions.