Study On The Correlation Between The Serum Uric Acid And Cystatin C And Hypertensive Intracerebral Hemorrhage

ObjectiveTo investigate the relationship between the serum uric acid as well as Cystatin C level and hypeitensive cerebral hemorrhage.MethodsA total of 197 patients diagnosed with hypertensive intracerebral hemorrhageage and aged30-80 years who were admitted to the First Affiliated Hospital of Shantou University Medical College from January 2017 to January 2020 were included.The study then collected 238 hypertensive patients who didn’t suffered from intracerebral hemorrhageage in the same period and at the same levels of age.A total of 227 healthy people in the same period and age were randomly selected as the control group.The levels of serum uric acid and Cystatin C were detected by peripheral blood immunoassay.SPSS25.0 was used to analyze whether there were differences in the mean values of the levels of serum uric acid and cystatin C among the three groups.Then analyze whether there is difference of composition ratio between these patients with different gender and different groups.In addition,the levels of serum uric acid and cystatin C in different hematoma sites and different hematoma volumes were statistically analyzed by stratification.Finally,multivariate logistic regression analysis was used to determine the risk factors for the occurrence of HICH,and receiver operating characteristic curve(ROC)was used to analyze the predictive value of serum uric acid and cystatin C for the occurrence of HICH.ResultsThe levels of uric acid and cystatin C in the hypertensive group with cerebral hemorrhage were significantly higher than those in the hypertensive group without cerebral hemorrhage and the healthy control group,and the levels of uric acid and cystatin C in the hypertensive group without cerebral hemorrhage were also higher than those in the healthy control group,These statistics have statistical significance(P<0.05).By stratified comparison of the levels of uric acid and cystatin C in each group,the results showed that when the level of uric acid in adult men was greater than 420μmol/L,that of adult women was greater than 301μmol/L,or when the levels of serum cystatin C in all of adults was greater than 1.09mg/L,the probability of intracerebral hemorrhage was significantly increased.Through the study of the correlation between serum uric acid and cystatin C levels,it was found that the correlation between serum uric acid and cystatin C levels was positively correlated in the three groups of people,and this correlation was the highest in the healthy control group.Through the stratified study of the site of intracerebral hemorrhage and the amount of hematoma,The results showed that the serum uric acid level was higher in supratentorial intracerebral hemorrhage patients with more than 30 ml hematoma volume;Multivariate logistic regression analysis showed that serum uric acid,cystatin C,systolic blood pressure,pulse pressure,fasting blood glucose and triglyceride were independent risk factors for cerebral hemorrhage in patients with hypertension.Receiver operating characteristic curve(ROC)analysis showed that the area under curve(AUC)of cystatin C index was 0.707,and uric acid was 0.684.The predictive value of cystatin C was higher than that of uric acid in the incidence of hypertensive-intracerebral hemorrhage.The optimal diagnostic threshold of serum uric acid was 319.5μmol/L,the sensitivity was 75.1%,and the specificity was 58.9%.The optimal diagnostic cut-off value of serum cystatin C was 0.93mg/L,with a sensitivity of 49.7%and specificity of 83.4%.ConlusionElevated levels of serum uric acid and cystatin C are independent risk factors for cerebral hemorrhage in hypertensive patients,and increased levels of uric acid are correlated with the hematoma volume of supratentorial cerebral hemorrhage.Therefore,early monitoring and control of serum uric acid and cystatin C are of great significance for reducing the incidence of cerebral hemorrhage in hypertensive patients.