| Purpose: By observing the spleen tong bi soup for wet stasis type pixu(spleen deficient)in patients with type 2 diabetes peripheral neuropathy of glucose metabolism,lipid metabolism,nerve conduction velocity,Toronto,integral,the effect of TCM syndrome integral,clear the spleen through the clinical curative effect and safety of bi soup for clinical treatment of diabetic peripheral neuropathy provide new treatment options.Methods: In this study,the method of randomized control was adopted to select 70 patients who met the inclusion criteria as the research objects.The subjects were randomly assigned to two groups in a ratio of 1:1,including 35 cases in the treatment group and 35 cases in the control group.The control group received basic treatment plus oral mecobalamin tablets,and the treatment group received basic treatment plus oral jianpi tongbi decoction,taking 1 month as a course of treatment.Patients in both groups received 1 courses of treatment.The changes of glucose metabolism indexes,lipid metabolism indexes,nerve conduction velocity,symptoms and signs in 2 groups before and after treatment were observed.SPSS25.0statistical software was used to conduct statistical analysis of the data according to the established efficacy evaluation criteria.Results:1.Comparison of glucose metabolism indexes: FBG and 2HPG in the treatment group before and after treatment showed statistically significant differences(P<0.05),while Hb A1 c showed no statistically significant differences(P>0.05).There was no significant difference in glucose metabolism indexes in the control group before and after treatment(P>0.05).After treatment,there were statistically significant differences in glucose metabolism indexes between the two groups in FBG and 2HPG(P<0.05),while there were no statistically significant differences in Hb A1c(P>0.05).2.Comparison of lipid metabolism indexes: there was statistically significant difference in lipid metabolism indexes in the treatment group before and after treatment(P<0.05),while there was no statistically significant difference in lipid metabolism indexes in the control group before and after treatment(P>0.05).There was statistically significant difference in lipid metabolism between the two groups after treatment(P<0.05).3.Comparison of nerve conduction velocity: SCV and MCV of median nerve and SCV and MCV of peroneal nerve in the treatment group and the control group before and after treatment showed statistically significant differences(P<0.05).After treatment,SCV and MCV of median nerve and SCV and MCV of peroneal nerve were not significantly different between the two groups(P>0.05).4.Comparison of Toronto scores: there were statistically significant differences in Toronto scores between the treatment group and the control group before and after treatment(P<0.05);After treatment,the difference in Toronto score between the two groups was statistically significant(P<0.05).5.Comparison of individual TCM syndrome scores: the comparison of total TCM syndrome scores in the treatment group before and after treatment showed statistically significant difference(P<0.01);The comparison of total TCM syndrome scores in the control group before and after treatment showed statistical significance(P<0.05).After treatment,there was a statistically significant difference in total TCM syndrome scores between the two groups(P<0.01).The scores of TCM syndromes in the treatment group before and after treatment showed statistically significant differences(P<0.01).Comparison of TCM syndrome scores of the control group before and after treatment showed statistically significant differences in TCM syndrome scores of 6 items(limb pain,limb numbness,shortness of breath and lazy speech,sticky mouth,purple and dark lips,and wrong skin),and comparison of TCM syndrome scores of 3 items(tiredness and weakness,abdominal distention and sticky stool).The difference was not statistically significant(P>0.05).The TCM syndrome integral comparison the two groups after treatment,six(lazy languid,shortness of breath,often abdominal distension full,sticky mouth,oral,defecate viscous dark purple)of TCM syndrome integral comparison,the difference was statistically significant(P < 0.05),3(body pain,numbness,skin a wrong)TCM syndrome integral,there was no statistically significant difference(P > 0.05).6.Comparison of total scores of TCM syndromes: the comparison of total scores of TCM syndromes in the treatment group before and after treatment showed statistically significant difference(P<0.01);The comparison of total TCM syndrome scores in the control group before and after treatment showed statistical significance(P<0.05).After treatment,there was a statistically significant difference in total TCM syndrome scores between the two groups(P<0.01).7.Comparison of clinical efficacy: the effective rate of the treatment group was 90.91%,and the effective rate of the control group was68.75%.Comparison of clinical efficacy between the two groups showed statistical significance(P<0.05).8.Safety comparison: During the whole clinical observation process,there were no adverse conditions in the treatment of the two groups,and there were no abnormal safety indicators in the two groups.Conclusions :1.Jianpi Tongpi Decoction can reduce TCM syndrome score and Toronto score of patients with peripheral neuropathy of type 2diabetes mellitus with spleen deficiency and dampness-stasis,improve nerve conduction velocity,and reduce fasting blood glucose,2h postprandial blood glucose,total cholesterol,triglyceride,and low density lipoprotein cholesterol levels,with positive clinical efficacy,better than mecobalamine group.2.Jianpi Tongbi Decoction has good safety,no obvious toxic and side effects,and is worthy of clinical promotion and application. |
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