Clinical Observation Of Modified Chaihu Wendan Decoction In The Treatment Of Ventricular Prephase Systolic(Faint-hearted)Patients

Objective:To observe the effects of Modified Chaihu-Wendan Decoction on the total TCM symptom score,TCM single symptom score,the number of ventricular prephase contraction in 24 hours dynamic electrocardiogram,the LOWN classification of ventricular prephase contraction and the Conciscent Scale of Quality of Life(SF-12)of patients with ventricular prephase contraction(heart deficiency and timor type),and to evaluate its efficacy and safety Methods:Patients aged between 18 and 60 years old who met the Western medicine diagnostic criteria of ventricular prephase contraction and the Chinese medicine diagnostic criteria of heart palpitation were selected as the research subjects.They were randomly divided into the treatment group and the control group,30 people in each group.The treatment group was given orally modified Chaihu-Wendan Decoction,and the control group was given betalloc treatment for 4 weeks.The changes of TCM symptom score,TCM symptom score,24 hours dynamic electrocardiogram(DECG)number of ventricular prephase contraction,LOWN grade of ventricular prephase contraction and SF-12 were observed and recorded before and after treatment.To evaluate the clinical effect of Modified Chaihu-Wendan Decoction on patients with ventricular prephase contraction(timid type).Results:1.Therapeutic effect of TCM symptoms: Before treatment,there was no significant difference between total TCM symptom score and single symptom score between the two groups(P > 0.05);After treatment,the total symptom score and individual symptom score in the treatment group decreased more significantly than that in the control group,with statistically significant difference(P < 0.05).The effective rate of TCM syndrome in the treatment group was 92.86%,and the effective rate of TCM syndrome in the control group was 71.43%,with statistically significant difference(P < 0.05).2.24-hour dynamic electrocardiogram efficacy: Before treatment,there was no significant difference in 24-hour dynamic electrocardiogram efficacy between the two groups(P > 0.05);After treatment,10 patients in the treatment group showed significant effect,15 patients were effective,3patients were ineffective,and the effective rate was 89.29%;2 patients in the control group showed significant effect,16 patients in the treatment group,and 10 patients in the control group,and the effective rate was 64.29%.There was significant difference in the effective rate of 24 hours dynamic electrocardiogram between the two groups after 4 weeks of treatment(P <0.05).3.Lown grading efficacy: Before treatment,there was no significant difference in Lown grading efficacy between the two groups(P > 0.05);After treatment,the effective rate was 89.29% in the treatment group(7 cases),effective rate was 18 cases and ineffective rate was 3 cases in the treatment group;the effective rate was 53.58% in the control group(1 case),effective rate was 14 cases and ineffective rate was 13 cases.After 4 weeks of treatment,there was a significant difference in the effective rate of LOWN grading between the two groups(P < 0.05).4.Quality of life score(SF-12)Efficacy: Compared with before treatment,SF-12 score in 2 groups was significantly decreased(P<0.05);After treatment,the SF-12 score in the treatment group was significantly lower than that in the control group(P<0.01).4.Conclusion:1.Modifying Chaihu-Wendan Decoction can reduce the total TCM symptom score and single TCM symptom score of patients with ventricular prephase contraction(guilt-deficient cowardice type),and reduce clinical symptoms.2.Modified Chaihu-Wendan Decoction can reduce the frequency of premature beats in patients with ventricular prephase contraction(timid type)and improve the clinical symptoms of patients;3.Modified Chaihu-Wentan Decoction can reduce the LOWN grading degree of patients with ventricular prephase contraction(timid type);4.Modified Chaihu-Wentan Decoction can improve the quality of life of patients with ventricular prephase contraction(shyness type);5.Modified Chaihu-Wendan Decoction has no adverse reactions and is safe and reliable.